成人免疫性血小板减少症骨髓巨核细胞数变化与治疗效果的关系

摘要

目的 探讨成人免疫性血小板减少症患者骨髓巨核细胞数变化与治疗效果的关系.方法 选择2009年1月至2013年6月成人免疫性血小板减少症患者140例为研究对象,所有患者治疗前均行骨髓巨核细胞涂片检查,巨核细胞数＜7个/4.5 cm2者为Ⅰ组,巨核细胞数7 ～ 35个/cm2者为Ⅱ组,巨核细胞数＞ 35个/cm2者为Ⅲ组,三组患者均采用相同的方案进行治疗,对比三组患者的治疗效果.结果 Ⅰ、Ⅱ、Ⅲ组总有效率分别为25.00％,76.47％,93.33％,Ⅰ组与Ⅱ组、Ⅰ组与Ⅲ组、Ⅱ组与Ⅲ组总有效率比较差异均有统计学意义(x2值分别为9.961、40.279、5.424,P＜0.01或0.05).结论 成人免疫性血小板减少症患者的骨髓巨核细胞数变化对治疗效果有很大的影响,其中骨髓巨核细胞数增殖有利于治疗.%Objective To investigate the relationship between the changes of bone marrow megakaryocyte count and therapeutic effect in adults with immune thrombocytopenia.Methods From January 2009 to June 2013,140 adult immune thrombocytopenia patients were selected as the research objects,all of the patients were performed with bone marrow megakaryocyte smears before treatment,the number of megakaryocyte ＜ 7/4.5 cm2 as group Ⅰ,megakaryocyte number was 7-35 / cm2 as group Ⅱ,megakaryocyte number ＞ 35/cm2 classified as group Ⅲ,three groups of patients were treated in the same solution,the treatment effects of three groups of patients were compared.Results The total effective rate of group Ⅰ,Ⅱ and Ⅲ was 25.00％,76.47％ and 93.33％,the difference was significant between group Ⅰ and Ⅱ(x2=9.961,P＜0.01),group Ⅰ and Ⅲ(x2 =40.279,P＜0.01),group Ⅱ and Ⅲ (x2 =5.424,P ＜ 0.05).Conclusions The number of bone marrow megakaryocyte in adult patients with immune thrombocytopenia has great influence on the therapeutic effect,proliferation of bone marrow megakaryocyte is beneficial to treatment.