子宫内膜异位症相关性卵巢癌的研究现状及展望

摘要

子宫内膜异位症(内异症)是最常见的妇科疾病之一.内异症恶变与卵巢透明细胞癌和卵巢子宫内膜样癌存在密切联系,甚至被认为是后者的癌前病变.既往临床研究显示内异症相关性卵巢癌(endometriosis associated ovarian carcinoma,EAOC)患者有某些特殊的临床病理特点,预后相对较好;基础研究发现某些特殊的基因异常表达与其相关.后续研究应着重于从EAOC发现新的分子分型靶点,以便指导临床筛选内异症恶变高危人群、预测疾病进展、实现此类卵巢癌的精准分型和分层管理.%Endometriosis is one of the most comnon benign gynecologic diseases.Malignant changes of endometriosis (EM)are considered to have close relationship with ovarian clear cell carcinoma and endometrioid adenocarcinoma,and EM is regarded as the precursor lesion of OCCC.Previons clinical studies showed endometriosis-associated ovarian cancer (EAOC) patients have some special clinical and pathological features,and prognosis is good.And the basic research found that certain abnormal expression of genes was related to EAOC.Future research might focus on exploring new molecular target of EAOC,so as to guide the clinical screening of high risk population,predict disease progression,and help to build the precise classification system of ovarian cancer and the strategy of stratified management.