Endometriosis and the risk of malignancy, especially ovarian cancer

摘要

The purpose of this study was to determine the risk of malignancies in a large cohort of patients with endometriosis through long-term follow-up. Results: This extensive Swedish, national registry study comprising 64,492 women (766,556 person-years) diagnosed with endometriosis between 1969 and 2000, and followed for a mean of 12 7 years, showed a significantly increased risk of ovarian cancer, other endocrine types of cancer (i.e in the adrenals, parathyroid glands, thymus, the pituitary gland, and pancreas), non-Hodgkin's lymphoma, and brain tumours The risk Of ovarian cancer was highest in women with ovarian endometriosis, but was also increased in women with other types of endometriosis; the risk was reduced in women with adenomyosis Women with a hysterectomy before or at the same time as the endometriosis diagnosis had no increased risk of ovarian cancer The risk of cervical cancer was reduced. Conclusion: Women with endometriosis have an increased risk of certain types of malignancy, in particular ovarian cancer. Hysterectomy appears to have a preventive effect.