Objective To study the significance of the expression of β-catenin(β-cat) in Barrett esophagus and esophageal adenocarcinoma (EAC) and the relationship between its expression and clinicopathological factom.Methods By using SP immunohistochemistry technique,β-cat wag detected in the normal esophageal mucosa group (20 cases),Barrett esophagus with dysplasia group (26 cages) and EAC group (50 cases).Results The membranous expression of β-cat appeared in all of nomal esophageal mucosa.The rate of cytoplasmic and/or nuclear expression of β-cat in the Barrett esophagus with dysplasia group and the EAC group was 38.5% (10/26) and 60.0% (30/50) respectively,and compared with the normal esophageal mucosa group,the difference was signfficant (P＜0.01).The rate of cytoplasmic and/or nuclear expression of β-cat in the EAC group with lymphatic metastasis and the EAC group exceeding deep smooth muscle was 90.0% (18/20) and 72.2%(26/36) respectively,and compared with that in the nonlymphatic metastasis and the non-exceeding deep smooth muscle patients [43-3%(13/30) and 28.6% (4/14)],the difference was significant (P＜0.01).Conclusion Cytoplasmic and/or nuclear expression of β-cat might play a role in the carcinogenesis and progression of EAC and might be a predictor indicating the metastatic potential of EAC.%目的 探讨β-连环蛋白在Barrett食管及食管腺癌中的表达以及与食管腺癌各种临床病理因素之间的关系.方法 免疫组织化学方法分别测定正常食管黏膜20例、Barrett食管伴异型增生26例、食管腺癌50例中β-连环蛋白的表达.结果 β-连环蛋白在20例正常食管黏膜上皮细胞呈细胞膜阳性表达,异位表达率为0,在Barrett食管、食管腺癌m现细胞质和/或细胞核异位表达,异位表达率分别为38.5%(10/26)、60.0%(30,50),明显高于正常食管黏膜(P＜0.01).食管腺癌中有淋巴结转移、浸润深度超过深肌层患者β-连环蛋白异位表达率分别为90.0%(18/20)、72.2%(26/36),明显高于无淋巴结转移、浸润深度未超过深肌层患者的43.3%(13/30)、28.6%(4/14)(P＜0.01).结论 β-连环蛋白异位表达可能参与了食管腺癌的发生,可以作为预测食管腺癌转移潜能的一个参考指标.
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