加减逍遥散治疗肝郁脾虚证慢性乙型肝炎疗效观察

摘要

Objective To observe the clinical effection of modified Xiaoyaosan in treating chronic hepatitis B with Syndrome of liver stagnation and spleen deficiency. Methods 60 patients of chronic hepatitis B with syndrome of liver stagnation and spleen deficiency were chosen for clinical observation, and randomly divided into experimental group and control group. After12 weeks' treatment, to observe the patients' improvements such as clinical symptoms,biochemical indicators, immunological targets, pathogen indicators and so on. Results After the treatment of 12 weeks, the total efficiency of experimental group is 83.33％, and 66.67％ of the control group. Experimental group was significantly better than the control group(P ＜0.05). The experimental group is superior to the control group in the improvement in Syndrome of TCM, biochemical, immunological indicators and HBV-DNA negative conversion rate, and there are statistical differences between the two groups (P ＜0.05). Conclusion Modified xiaoyaosan can effectively improve Syndrome of TCM, regulate cell immunity, restore liver function and enhance anti-viral response rate.%目的 观察加减逍遥散治疗肝郁脾虚证慢性乙型肝炎临床疗效.方法 临床以60例肝郁脾虚证慢性乙型肝炎患者为研究对象,随机分为试验组和对照组各30例.观察患者治疗12周后的临床证候、生化指标、免疫学指标、病原学指标等的改善情况.结果 治疗12周时试验组总有效率83.33%,对照组为66.67%,试验组明显优于对照组(P<0.05).试验组在改善中医证候、生化指标、免疫指标、HBV-DNA转阴率等方面明显优于对照组,二者有统计学差异(P<0.05).结论 逍遥散加减方可有效改善中医证候、调节细胞免疫、恢复肝功能、提高抗病毒的应答率.