主动脉结合性质导致药物副作用的研究进展

摘要

Some drugs, such as hydralazine, imidazole, muzolimine, rofecoxib, AZD5248 and ZD4407, have aortic binding character. The mechanism by which aortic binding impairs of elastin formation is analyzed here.Aortic binding research methods,such as[14C]labeled compound quantitative analysis,quantitative whole body autoradiography studies,in vitro benzaldehyde and propionic aldehyde reactivity assay and in vitro[14C]labeled compound competitive aortic tissue binding assay,are summa-rized.Studies show that aorta binding may induce side effects of drugs,which should become a health concern.%有些药物具有主动脉结合性质,如肼屈嗪、咪唑、莫唑胺、罗非昔布、AZD5248和ZD4407.本文对其破坏弹性蛋白正常形成的主动脉结合机制进行了分析,并对[14C]标记化合物定量分析、全身定量自显影研究、体外苯甲醛、丙醛结合模拟分析及体外[14C]标记化合物竞争性结合分析等主动脉结合的体内外研究方法进行了归纳总结.提示具有主动脉结合性质的药物具有导致心血管疾病的副作用,应受到药物研发工作者的普遍关注.