先锋霉素珠链治疗小儿慢性化脓性骨髓炎

摘要

Experiments in vitro and in vivo revealed that Cephaloridine or Cefazoline combined with Polymethylmethacrylate (PMMA)will release,in the body continuously,a therapeutic concentration inhibiting several kinds of pathogenic bacteria for at least 8 weeks,This drug-combination has been successfully made in form of beads which are later made into a chain,so call "beads-chain".From 1985 to 1987,32 children with aucte or chronic osteomyelitis were treated with Cephaloridine or Cefazoline-PMMA "beads-chain".Among them,31 were cured.After a thourough debridement,the "beadschain" is imbedded in the sutured wound along its whole length of the tract leaving two beads extending outside the skin.7 days later,2 of 3 beads are pulled out and removed every other day,and this chain will be removed completely within 2 to 3 weeks and the sinus will heal in 4 of 5 days.This is a new method in the treatment of acute of chronic osteomyelitis and also in the prevention of bone and soft tissue infections in open fractures.%1985年至1987年底,在彻底清除病灶的基础上,应用先锋霉素珠链治疗小儿慢性骨髓炎27例,全部治愈.本文结合临床资料,对小儿慢性骨髓炎的病因、发病年龄、病程,放射学、细菌学、白细胞、血沉变化等病理特点进行了综合分析;结合实验研究与临床应用结果,对先锋霉素珠链治疗骨髓炎的作用机制与治疗效果,影响疗效的因素及值得注意的问题等,进行了详细讨论.