1955～1986年诊治200余例组织细胞增生症X,发现脊椎破坏者21例.发病年龄7个月～10岁.其中,骨嗜酸性肉芽肿10例,韩-薛-柯综合征7例,由前者发展成后者3例,介于后者与勒-雪综合征者1例.有8例误诊为脊柱结核.8例做过活组织检查.未经治疗7例中,5例恢复;11例采用化疗中,10例进步,1例死亡;3例有神经压迫症状者手术后继续化疗,全部恢复.对其发病情况、临床表现、诊治以及预后进行了讨论.%The authors reported 21 cases of spinal lesion out of 200 eases of histocytosis X in Beijing Children's Hospital from 1955 to 1986.The age of onset ranged from 7 months to 10 years in 13 males and 8 females.According to the pathological classification,10 were classified as EGB(Eosinophilic Granuloma of Bone),7 HSC(Hand-Schuller-Christia),3 EGB-HSC,1 HSC-LS(Lettere-Siwe).8 ca ses were misdiagnosed as spinal tuberculosis.X-ray examination was the main method for diagnosis.Pathological examination was performed on 8 cases.Among 7 cases without treatment,5 recovered,1 became worse and 1 lost for following up.11 cases were treated by chemotherapy,10 improved in a short period,1 died.3 cases with neurological dificit had surgical intervention followed by chemotherapy and recovered.The incidence,clinical menifestation,diagnosis,treatment and prognosis were discussed in this paper.
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