5-羟色胺在骨生物学的研究进展

摘要

5-Hydroxytryptamine (5-HT) , which is synthesized by two different genes at two different sites, is one of the monoamine compounds. The regulatory effects of S-HT on bone mass depend on the sites of synthesis. When produced peripherally, S-HT acts as a hormone to inhibit bone formation. However, when produced in the brain, it acts as a neurotransmitter to exert a positive effect on bone mass by enhancing bone formation and suppressing bone resorption. Inhibition of biosynthesis of the peripheral S-HT may be a novel therapeutic strategy to treat osteoporosis through strengthening the anabolism of bone. In this review, we summarize the current progress on the role of 5-HT in bone biology.%5羟色胺(5-Hydroxytryptamine，5-HT)是一种在体内两个不同部位采用两种不同基因合成的单胺类化合物，其骨量调节作用依赖于其合成部位。外周合成的5-HT可充当激素抑制骨形成，而中枢合成的5-HT则充当神经递质通过促进骨形成及抑制骨吸收来正向调控骨量。抑制外周5-HT的合成可能成为一种通过增强骨的合成代谢治疗骨质疏松的新型方法 。本文就5-HT在骨生物学的研究进展作一综述。