维生素K2与围绝经期骨质疏松症关系的研究进展

摘要

维生素K是一类具有叶绿醌生物活性的萘醌基团的衍生物,主要有两种存在形式,一种是叶绿醌,即维生素K1;另一类是甲基萘醌类,即维生素K2.近年来研究认为,维生素K2是围绝经期及绝经后骨质疏松症关键的影响因素,它通过将骨钙素中的谷氨酸残基羧化成γ-羧化谷氨酸残基促进骨形成;是骨特异性转录调节因子,促进了成骨细胞标志物的表达;并抑制骨吸收.这些结果为进一步研究围绝经期及绝经后骨质疏松症的治疗提供了新的根据,也为绝经期及绝经后骨质疏松症的治疗提供了新的靶点.%Vitamin K is one of naphthoquinone derivatives with phylloquinone activity.Natural Vitamin K exists in two forms: the phylloquinone( Vitamin K1 ) and menaquinone( Vitamin K2).Recent studies show that Vitamin K2 is a key influence factor in perimenopausal and post-menopausal osteoporosis.Vitamin K2 can promote the bone generation by turning the glutamate residues of Osteocalcin into γ-carboxyl glutamate residues.Vitamin K2 is a bone-specific transcription factor, and it promotes osteoblast marker expression,inhibits bone absorption.These new studies provide a new evidence and target for perimenopausal and postmenopausal osteoporosis treatment.