上海市绝经后妇女冬季维生素D状况

摘要

目的 调查上海市绝经后妇女在冬季(12月份)维生素D的状况.方法 在社区101例年龄63.7 ±7.0岁健康绝经后妇女中,检测血清25羟维生素D[25(OH)D]、甲状旁腺激素(PTH),同时检测血钙、磷、碱性磷酸酶、肝肾功能及空腹血糖.所有研究对象均用双能X线吸收仪检测腰椎和股骨近端骨密度(BMD),同时用问卷调查生活方式.结果 本研究101例绝经后女性血清25(OH)D平均值为17.09 ng/ml,PTH平均值51.0 pg/ml,维生素D缺乏者占(<20 ng/ml)68%,维生素D不足者(20～29 ng/ml)占了30%,只有2例维生素D充足(>30 ng/ml)占2%.PTH均值在维生素D缺乏组中(53.7 pg/ml)高于维生素D不足组(44.8 pg/ml),有统计学差异(P<0.05);但未发现血清25(OH)D与PTH有线性回归关系.同时未发现血清25(OH)D与血钙、BMD或BMI相关.结论 上海市健康绝经后妇女在冬季维生素D普遍不足,维生素D缺乏组的PTH显著高于维生素D不足组,不良的生活方式及低维生素D和钙的摄入应引起重视.%Objective We aimed to describe the vitamin D status of Shanghai postmenopausal women in winter (December). Methods Serum 25-hydroxyvitamin D and parathyroid hormone ( PTH), as well as serum calcium, phosphorus, alkaline phosphatase, hepatic and renal function, and fasting blood-glucose,were examined in 101 healthy postmenopausal women aged 63.7 ± 7.0 years in average. Bone mineral densities (BMDs) of the lumbar spine and the proximal femur were measured using dual-energy X-ray absorptiometry in all the women. All subjects were asked for life style with a questionnaire. Results The mean values of serum 25-hydroxyvitamin D and PTH were 17.09 ng/ml and 51. 0 pg/ml, respectively.Among our subjects, the incidence of vitamin D deficiency ( ＜ 20 ng/ml) was 68％. The incidence of vitamin D insufficiency (20-30 ng/ml ) was 30％. Sufficient vitamin D status ( ＞ 30 ng/ml ) was only account for 2％ ( in 2 women). Mean values of PTH were higher (53.7 pg/ml) in vitamin D deficiency group than those in vitamin D insufficiency group (44. 8 pg/ml ), with statistical difference ( P ＜ 0. 05 ).However, there was no linear correlation between 25-hydroxyvitamin D and PTH. No correlations were found between 25-hydroxyvitamin D and calcium, and between BMI and BMD. Conclusion Vitamin D deficiency is very common in postmenopausal women living in Shanghai in winter. PTH in vitamin D deficiency group was significantly higher than that in vitamin D insufficiency group. Unhealthy lifestyle and low calcium and vitamin D intakes should be taken into account.