非高密度脂蛋白胆固醇与碱性磷酸酶水平的调查与分析

摘要

Objective To investigate the serum levels of non -high density lipoprotein cholesterol ( non-HDLC ) and alkaline phosphatase ( ALP) of population in a university in Guangzhou, and to analyze the inner relationship between two markers combining with atherogenic index of plasma ( AIP). Methods Clinical data of 505 people, who attended to physical examination in our hospital from 2011 to 2012, were prospectively studied and analyzed. Serum levels of total cholesterol ( TC ), triglyceride ( TG ), high density lipoprotein cholesterol ( HDL-C ), and low density lipoprotein cholesterol (LDL-C) were detected according to standard operating procedures. ALP levels were also detected. And then non-HDLC level was calculated according to the formulae. Non-HDLC levels and ALP levels in different groups were statistically analyzed combining with AIP. The predicating significance of non -HDLC on the evaluation of atherosclerosis and the correlation between ALP and blood lipid metabolism were analyzed. Results The serum levels of both non -HDLC and LDL-C showed no gender difference before 60 years old. But peak value of the serum levels appeared after 60 years old and showed gender difference. Non-HDLC was more closely and stably related to AIP than LDL -C as comparing TC and TG on different levels or without grouping. ALP was positively correlated with non -HDLC in both male and female groups over 60 years old (r = 0. 520, 0. 226, respectively, P ＜ 0. 001, P ＜ 0. 05). And only in males over than 60 years old, ALP was positively correlated with AIP ( r = 0. 717, P ＜ 0. 001). Conclusion Compared with using LDL -C alone, combining with the two indexes, non-HDLC and AIP, can improve the accuracy of atherosclerosis risk evaluation. Blood lipid metabolism is correlated with bone metabolism marker, ALP.%目的 调查广州某高校人群的非高密度脂蛋白胆固醇(non-HDLC)与碱性磷酸酶(ALP)水平,并结合血浆促动脉硬化指数(AIP)分析两指标的临床预测意义以及两指标之间的关系.方法 采用前瞻性研究对2011~2012年广州地区的某高校505例人群的完整体检资料进行统计分析,直接检测法得出血浆总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)等血脂的水平及ALP水平,根据公式计算出non-HDLC,结合AIP指数统计分析不同分组人群血浆non-HDLC水平和ALP水平,探讨non-HDLC对动脉粥样硬化评估的临床预测意义,以及骨代谢指标ALP与血脂之间的关系.结果 血脂non-HDLC、LDL0C水平60岁以前同年龄层不存在性别差异,血脂水平都在60岁以后出现高值,且存在性别差异;无论对血脂正常人群按TC或TG分层与否,与LDL-C,non-HDLC都呈现出与AIP更稳定更密切的相关性.60岁以上的男性、女性人群中ALP与血脂non-HDLC均呈正相关(r=0.520、0.226,P<0.001、P<0.05),而男性仅60岁以上的ALP值与AIP呈正相关(r=0.717,P<0.001).结论 较以往单凭LDL-C值的判断,血脂non-HDLC值和AIP值的结合判断能提高临床上对动脉粥样硬化危险性评估的准确性.血脂与骨指标ALP也存在着密切的关系.