中青年2型糖尿病患者血脂与骨密度关系

摘要

目的 探讨中青年2型糖尿病患者血脂与骨密度的相关性.方法 将230例中青年2型糖尿病患者按骨密度测定分成骨质疏松组和非骨质疏松组;检测两组患者血清总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及骨密度和常见生化指标,如血糖和糖化血红蛋白、钙磷和肝肾功能,分析血脂各成分与骨密度之间的关系.结果 (1) 中青年2型糖尿病患者体重指数与骨密度存在显著正相关(r= 0.256,P<0.01),而年龄、HDL-C与骨密度存在显著负相关(r1=-0.298,P1<0.01;r2=-0.237,P2<0.01);TC、TG、LDL-C与骨密度均无相关性.(2) 在校正年龄、BMI等因素后,HDL-C仍与骨密度呈负相关(r=-0.152,P<0.05).结论 中青年糖尿病患者HDL-C增加可能与骨密度降低有一定的关系,而年龄增大可导致骨质疏松发生的增加,体重指数增加可减少骨质疏松发生的增加.%Objective To investigate the correlation between serum lipid level and bone mineral density (BMD) in young and middle-aged patients with type 2 diabetes. Methods 230 young and middle-aged patients with type 2 diabetes were divided into two groups, according to T score ; osteoporosis group ( T ≤ -2. 5) and non-osteoporosis group ( T ＞ -2.5); the levels of serum total cholesterol ( TC ) 、 triglyceride ( TG ), high density lipoprotein cholesterol ( HDL-C ) 、 low density lipoprotein cholesterol ( LDL-C ) and BMD And other biochemistry markers such as fasting blood glucose, glycated hemoglobin, blood calcium and phosphoremia, liver and renal function, were determined. the correlation between serum lipids and BMD were analyzed. Results ( 1) in young and middle-aged patients with type 2 diabetes, BMI is positive correlations with BMD( r =0. 256,p ＜0. 01),but the age and HDL-C levels showed significantly negative correlations with BMD( r1 = - 0. 298,p1 ＜ 0. 01 ; r2 = - 0. 237,p2 ＜ 0. 01), while There were no relationships among the TC, TG, LDL-C levels and BMD. (2) After adjustment for age and BMI, the associations between HDL-C and BMD remained significant (r = -0. 152, P ＜0. 05). Conclusions in young and middle-aged patients with type 2 diabetes, the higher HDL-C maybe related to decreased BMD, the incidence of osteoporosis increases with age but decreases with higher BMI.