血脂紊乱与骨质疏松关系的研究进展

摘要

骨质疏松是一种常见的老年病，血脂紊乱常与其伴随出现。越来越多的研究显示二者之间可能存在一定的关系，不同类型的血脂紊乱对骨质疏松影响不一。高甘油三酯对男女性腰椎、股骨骨密度有不同的影响；低密度脂蛋白胆固醇影响骨细胞分化，低密度脂蛋白胆固醇增高可抑制成骨细胞活性，同时使破骨细胞活性增强从而引起骨质疏松；高密度脂蛋白胆固醇与骨质疏松的关系结论尚不一致。此外，他汀类药物可以促进成骨细胞分化，抑制破骨细胞活性从而增加骨密度，降低骨折风险；双膦酸盐在治疗骨质疏松的同时对血脂紊乱也有一定的影响。因此，研究血脂紊乱与骨质疏松之间的关系对于骨质疏松的防治具有一定的临床指导意义。%Osteoporosis is a common disease in the old people, in which dyslipidemia is always accompanied with.More and more researches reveal that certain correlation exists between them, and the effect of different lipid disorder on osteoporosis is different. The effect of hypertriglyceridemia on bone mineral density in men and women is also variable.Low density lipoprotein cholesterol ( LDL-C) can affect bone cell differentiation.The increase of LDL-C can inhibit the activity of the osteoblasts, and improve the activity of the osteoclasts, thus causing osteoporosis.The relationship between high density lipoprotein cholesterol and osteoporosis is still uncertain.In addition, statins can promote the osteoblast differentiation and inhibit the osteoclast activity, resulting in the increase of bone mineral density and decreased risk of fractures.Biphosphonates can affect dyslipidemia in the treatment of osteoporosis.Therefore, further researches of the relationship between dyslipidemia and osteoporosis will provide clinical guide for the prevention and treatment of osteoporosis.