绝经后女性雌二醇水平与膝骨性关节炎的相关性研究

摘要

Objective To explore the correlation between of serum estradiol level and severity of osteoarthritis (OA) in postmenopausal females.Methods A total of 121 postmenopausal females with OA were divided into mild group (n =35),moderate group (n =44),and severe group (n =42),according to K-L grades of the knee joint.Thirty-five normal postmenopausal women who underwent physical examination were selected as control.Fasting blood were extracted from all the subjects to detect E2,FBG,TC,LDL-C,HDL-C,and TG.In the experimental group,X-ray radiography of the knee was performed with uDR.MR T2-mapping imaging of the knee was performed with PHILPS 3.0T Ingenia Ⅱ.The WOMAC scale for the knee joint function was assessed.The data were analyzed with a SPSS19.0 software.Results (1) The level of E2 in postmenopausal KOA group was significantly lower than that in normal group (P =0.000).(2) In KOA group,with the severity of the lesion,serum E2 levels decreased,and WOMAC scores and T2 values increased.The levels of serum E2 were negatively correlated with WOMAC scores and T2 values (r =-0.651 and-0.501,respectively).Conclusion Estradiol levels in postmenopausal KOA patients were negatively correlated with the severity of KOA.%目的 研究绝经后女性雌二醇水平与膝骨性关节炎(knee osteoarthritis,KOA)发病严重程度的相关性.方法 选择121例绝经后女性膝骨性关节炎患者作为试验组,根据膝关节X线平片Kellgren-Lawrence(K-L)分级将其分为轻度组(35例)、中度组(44例)及重度组(42例).选择35名健康查体的正常绝经后女性作为对照组.所有受试者均采集空腹血液测定血清雌二醇(estradiol,E2)、空腹血糖(fasting blood glucose,FBG)、总胆固醇(triglyceride,TC)、低密度胆固醇(low density lipoprotein cholesterol,LDL-C)、高密度胆固醇(high density lipoprotein cholesterol,HDL-C)、甘油三酯(triglyceride,TG);试验组人员采用联影X射线成像系统(uDR)行膝关节平片,采用飞利浦3.0T磁共振IngeniaⅡ行膝关节磁共振T2mapping成像,并用WOMAC评分量表行膝关节功能评定.所得数据采用SPSS 19.0软件进行统计分析.结果 (1)绝经后KOA组的E2水平显著低于正常组的E2水平(P =0.000).(2) KOA组随病变严重程度增加,血清E2水平下降,WOMAC评分及T2值升高;血清E2水平与WOMAC评分及T2值均呈显著负相关(r=-0.651、-0.501).结论 绝经后女性KOA患者雌二醇水平与KOA严重程度呈负相关.