四川高原藏族人群和盆地汉族人群血清维生素D水平比较

摘要

Objective To investigate the vitamin D status of Han in the plains and Tibetan in the highlands in Sichuan, to analyze the influence of area and ethnic factors, and provide more reasonable guides for the supple-ment of vitamin D.Methods According to multistage stratified random sampling method, 325 Han and Tibetan people in Chengdu Plain and in Shiqu county were selected.Serum level of 25OHD were obtained in April 2012 and July 2012 respectively. All the subjects were divided into 3 groups based on the 25 OHD cut-off values:<50 nmol/L, <75 nmol/L, <150 nmol/L, respectively corresponds the three vitamin D status:deficient, inade-quate, and appropriate, to find out the vitamin D status in Sichuan, explore the influence factors of the vitamin D status.The differences between Han and Tibetan were compared, and the differences between Chengdu plain and Western Sichuan Plateau were also compared.Results The age of 325 subjects (176 Tibetan and 149 Han) was from 6 to 76 years old, with the mean age of 27.42 ±17.71 years old and the mean serum 25OHD was 50.52 ± 16.56 nmol/L.The results of vitamin D status assessed with three different values showed that vitamin D level of people in deficient, inadequate, and appropriate status was 53.23%, 40.62%, and 6.15%, respectively.Over-all, the results of serum 25OHD had significant difference between highland Tibetan and plain Han in Sichuan region (P value of 0.004), where there was a significant difference in female population with the test P value of 0.000, but no significant difference in male population.Conclusion The vitamin D status of people in Sichuan region is in poor condition.Because of food, custom and geographical environment difference, the vitamin D status of Tibetan people in western Sichuan highland is in worse condition .%目的：了解四川平原地区汉族和高原地区藏族人群血清维生素D水平现状及其差异，为指导合理补充维生素D提供依据。方法采用随机分层整群抽样方式，抽取四川省成都市平原地区汉族和四川省石渠县川西高原藏族人群共325份血液标本，采用酶联免疫法进行血清25 OHD检测。以25 OHD＜50 nmol/L、50～75 nmol/L和75～150 nmol/L分别定义为维生素D缺乏、不足和适宜，检测上述人群血清维生素D水平，并探索影响因素，比较地域和民族间差异。结果325名受试者纳入本研究，受试者年龄6～76岁，平均年龄（27.42±17.71）岁，其中藏族受试者176名（54.15％），汉族受试者149名（45.86％）。成都市平原地区汉族受试者血清25OHD 平均为（52.73±17.47） nmol/L，高原藏族受试者血清25OHD 平均为（48.65±15.55） nmol/L，经Kolmogorov-Smirnov Test检验，平原汉族和高原藏族人群血清25OHD均呈正态分布， P值分别为0.144和0.567。维生素D缺乏者占53.23％，不足者占40.62％，适宜者占6.15％。高原藏族和平原汉族人群血清25 OHD 比较差异有统计学意义（ P＝0.004），其中女性人群差异有显著统计学意义（ P＝0.000），男性人群差异无统计学意义（ P＝0.726）。结论四川省不同地区人群维生素D水平普遍较低，与平原汉族人群相比，高原藏族人群维生素D缺乏更为明显。