飞秒激光准分子激光原位角膜磨镶术后早期黄斑区视网膜及视网膜神经纤维层厚度观察

摘要

Objective To evaluate the changes of retinal nerve fiber layer and macular parameters after femtosecond laser-assisted laser in situ keratomileusis (fs-LASIK) assessed by spectral-domain optical coherence tomography (SD-OCT).Methods This prospective,consecutive study included 17 patients (33 eyes) with high (greater than-6.00 D) myopia treated with fs-LASIK.The macular thickness and volume and RNFLT measurements were performed using RTVue-100 OCT preoperatively and then on 1 day,1 week and 1 month postoperation.The measurements before and after fs-LASIK were compared using one-way analysis of variance (ANOVA).Results None of the RNFL parameters of whole,temporal,upper,nasal and below were observed to have a statistically significant change after fs-LASIK surgery (F=0.003,0.503,0.285,0.164,0.277,P＞0.05).Also,there was no statistically significant difference in macular thickness (F=0.491,0.281,0.234,0.341,0.614,0.192,P＞0.05) and volum (F=0.484,0.968,0.200,0.314,0.622,0.206,P＞0.05) of central fovea,parafovea,temporal,upper,nasal and below between pre-and postoperatively.Conclusion Femtosecond laser-assisted laser in situ keratomileusis has no significant effect on retinal nerve fiber layer and macular parameters determined by SD-OCT.%目的 比较飞秒激光准分子激光原位角膜磨镶术(LASIK)前后视网膜神经纤维层(RNFL)厚度和黄斑区视网膜参数的变化.方法 前瞻性连续病例研究.选择接受飞秒激光LASIK术的高度近视眼患者17例(33眼)(等效球镜度＞-6.00 D),采用RTVue-100频域光学相干断层成像仪(OCT)观察术眼术前、术后1d、1周及1个月时RNFL厚度以及黄斑厚度和容积变化.采用单因素方差分析比较手术前后测量参数的变化.结果 RNFL厚度(全部、颞侧、上方、鼻侧、下方)术前与术后各时间点差异无统计学意义(F=0.003、0.503、0.285、0.164、0.277,P＞0.05).黄斑区(包括中心凹、旁中心凹、颞侧、上方、鼻侧、下方)视网膜厚度(F=0.491、0.281、0.234、0.341、0.614、0.192,P＞0.05)及容积(F=0.484、0.968、0.200、0.314、0.622、0.206,P＞0.05)术前与术后1d、1周、1个月各时间点差异均无统计学意义.结论 飞秒激光LASIK手术对RNFL厚度和黄斑区视网膜参数无明显影响.