交感性眼炎的免疫发病机制与治疗研究进展

摘要

Sympathetic ophthalmia is a rare bilateral granulomatous inflammation that follows accidental or surgical insult to the uvea of one eye.Onset of sympathetic ophthalmia can be insidious or acute,with variable clinical manifestations.Sympathetic ophthalmia can deteriorate repeatedly and induce blindness.Clinical presentation shows mutton-fat keratic precipitates,choroidal infiltrations,and Dalen-Fuchs nodules.Histopathology reveals diffuse or nodular granulomatous inflammation of the uvea.Prevention and treatment strategies for sympathetic ophthalmia include medicine and surgery.The mechanism of the disease is still unclear but is largely thought to be autoimmune in nature.%交感性眼炎是一眼发生眼球穿通伤或内眼手术后引起的双眼非坏死性肉芽肿性葡萄膜炎.可隐匿发病也可急性发病.交感性眼炎临床表现多变,病情易于反复恶化,并可能致盲.典型的临床表现为羊脂状角膜后沉着物,脉络膜渗出及Dalen-Fuchs结节.组织学上表现为弥漫性或肉芽肿性葡萄膜炎症反应.目前的治疗包括药物治疗及手术治疗.发病机制目前尚未完全清楚,多认为是激发眼引起的自身免疫反应导致交感眼发病.