Used for the study of immune pathogenesis of lesions human tissue-specific and a method for manufacturing a multi-chimeric mice

摘要

The present invention relates to a method for manufacturing a multi-chimeric mouse and a functional tissue is restrained (HLA molecule) class II MHC class I and / or the only heterologous immune system functional heterologous (human). The invention also relates to the use of the multi-chimeric mouse can for studying immune pathogenesis of the disease (autoimmune disease infectious, or neoplastic) tissue-specific, to be obtained by the above method, as well as vaccines against these diseases or for testing, on the Application of their design and immunotherapeutic agents.