单纯疱疹性角膜炎活动期行穿透性角膜移植术的疗效评价

摘要

目的　评价复发型单纯疱疹性角膜炎（herpes simplex keratitis, HSK）基质型活动期行穿透性角膜移植术的治疗效果。方法　对66例（66只眼）HSK基质型活动期患者行穿透性角膜移植术（penetrating keratoplasty, PKP），并与同期59例（59只眼）HSK基质型稳定期的PKP术后患者的疗效进行对比。结果　两组HSK患者术后角膜植片透明率、原发病复发率及视力间比较差异无显著性（P>0.05）。结论　HSK基质型活动期行PKP术，只要术前和术中处理得当，不仅可缩短病程和减少并发症，而且还能取得与HSK基质型稳定期行PKP手术同样的疗效。%Objective　To evaluate the efficacy of penetrating keratoplasty (PKP) in treating active herpes simplex stromal keratitis. Methods　PKP was performed on 59 patients with quiescent and 66 patients with active herpes simplex stromal keratitis. The results and complications of herpes simplex keratitis (HSK) in the quiescent group were compared with that of the HSK active group. Results　No clinical or statistical significant differences in visual outcome, graft transparent rate and recurrent rate of HSK after operation were identified between the active and quiescent groups. Conclusion　When the pre- and intra-operative managements of PKP are properly performed on active HSK, the same results as that performed on quiescent HSK can be obtained, and it can reduce the complications and shorten the duration of the disease.