拓展年龄相关性黄斑变性发病机制的研究思路

摘要

在发达国家,年龄相关性黄斑变性(AMD)是50岁以上人群不可逆性严重视力下降的首要原因,是65岁以上人群主要的致盲眼病.随着我国经济水平的提高,进入老龄化社会的加速,AMD患者不断增多,日益受到全社会的关注.AMD的病因学和发病机制至今未明,是全世界眼科研究的热点.目前多数研究者认为环境与基因、氧化损伤、炎症免疫、血管生成与抑制生成因子失调等因素参与AMD的发生与发展.如何从纷繁复杂的相关因素中,探索我国人群AMD的发病机制是值得国内研究者认真关注的重要问题.笔者认为应善于从学术争议中寻找突破点,以拓展AMD发病机制的研究思路,为临床治疗AMD提供理论依据.%Age-related macular degeneration (AMD) is the leading cause of irreversible severe vision loss among people over the age of 50 and a major cause of blindness among people aged over 65 in developed countries.With the improvement of China's economic levels and entering the aging society with an acceleration speed,the growing number of AMD patients has become an increasing concern of the whole society.The etiology and pathogenesis of AMD are still not clear and this is a hot spot for ophthalmic research around the world.Currently thoughts that environment factors and genes,oxidative damage,inflammation,immune reaction,imbalance between angiogenesis factors and anti-angiogenesis factors,etc.are all involved in the occurrence and development of AMD.However,how to explore the pathogenesis of AMD in Chinese population from the complex reported literature deserved attention.The authors suppose that we should start from analysis of controversy and find a breakthrough in the dispute,to explore the pathogenesis of AMD in Chinese population.