Objective To estimate the prevalence rate and risk factors of diabetic retinopathy(DR) in residents at the age of ≥40 years in Luzhou,Sichuan Province.Methods A multistage,stratified cluster random sampling method was used to select 7 communities of 8002 permanent residents (≥40 years old) for diabetes screened from May to December 2011 in Luzhou,Sichuan Province.Reference to the diagnostic criteria for diabetes recommended by World Health Organization in 1999,to the 1374 diabetes screening out patients with questionnaire,physical examination,fasting plasma glucose,2-hours postprandial plasma glucose,glycosylated hemoglobin (HbAlc) and visual acuity,ocular diseases,fundus examination,etc.Some patients with fundus fluorescein angiography to the DR diagnosis,diagnostic criteria with reference to the diagnosis standard made by Chinese Oc ular Fundus Diseases Society,Chinese Ophthalmological Society,Chinese Medical Association in 1984.Rates between the groups were compared using x2 test,trend x2 test or Fisher exact test,using multivariate analysis of risk factors associated with DR screening.Results A total of 8002 people were c hosen and invited to take part in the project,7478 persons completed the study,the overall response rate was 93.48％.One thousand three hundreds and seventy-four persons were diagnosed as diabetic patients,which took the proportion of 18.37％ of the selected population,while 214 DR patients were found with the DR prevalence of 15.57％,occupying 2.86％ of the total.Of 214 patients,194 cases were non-proliferative diabetic retinopathy,making up 90.65％ of DR patients,while 7 cases were found to be proliferative diabetic retinopathy,constitute 9.35％ of DR patients.Multi-factor analysis manifest that there were close relationship between diabetic duration (trend x2 =189.21,P ＜ 0.01),the level of HbAlc (x2 =30.021,P ＜ 0.01),coronary heart disease (x2 =4.075,P =0.044) and DR prevalence.Conclusions The prevalence of DR is high in the diabetic residents in Luzhou,Sichuan Province.Diabetic duration,the level of HbAlc and coronary heart disease are the significant factors to influence DR development.These results indicate that the changes of the level of HbAlc are closely related to the genesis and development of DR among the diabetic patients.%目的 了解四川省泸州市40岁及以上自然人群中糖尿病视网膜病变(DR)的患病情况和影响因素.方法 分层整群随机抽样研究.2011年5-12月在四川省泸州市抽取3区4县的8002名40岁及以上的长住居民进行糖尿病普查.参照1999年世界卫生组织推荐的糖尿病诊断标准,对筛查出的1374例糖尿病患者进行问卷调查、体格检查、空腹血糖、餐后2h血糖、糖化血红蛋白(HbAlc)及视力、眼病、眼底等检查.部分患者采用荧光素眼底血管造影进行DR诊断,诊断标准参照1984年中华医学会眼科学分会眼底病学组制定的DR分期标准.各组间率的比较采用x2检验、趋势x2检验或Fisher确切概率法,采用多因素分析筛选DR的相关危险因素.结果 实际接受检查7478人,受检率为93.48％,检出糖尿病患者1374例,患病率为18.37％；DR患者214例,在糖尿病患者中的患病率为15.57％,在所有受检者中的患病率为2.86％.其中非增生性DR 194例,占接受检查DR患者的90.65％；增生性DR 20例,占接受检查DR患者的9.35％.多因素分析结果显示,糖尿病病程(趋势x2=189.21,P ＜0.01)、HbAlc水平(x2=30.021,P ＜0.01)、冠心病(x2=4.075,P=0.044)与DR的患病率有密切关系.结论 四川省泸州市糖尿病患者中DR患病率高；糖尿病病程、血糖水平及同时患有高血压病均是影响DR病情发展的重要因素；糖尿病患者的HbAlc水平的变化可能与DR发生、发展密切相关.
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