脉络膜转移癌短程放射治疗的短期疗效观察

摘要

Objective To observe and evaluate the therapeutic effect of brachytherapy for choroidal metastasis.Methods A restrospective case-series study.The data of 22 patients with 23 eyes of choroidal metastasis undergoing ruthenium 106 radioactive applicator brachytherapy were retrospectively analyzed from the Eye Center of People Hospital of Peking University from Feb.2004 and Sep.2012.Ocular tumor control,globe salvage rate and the visual acuity of the patients were observed and analyzed.Results Eighteen patients of 18 eyes were followed up.The median age of the 18 patients was 59 years and the median time of follow-up was 13 months.The remission of tumors with decreasing of subretinal fluid volume were obviously achieved and the globes were all reserved.At follow-up,13 patients' visual acuity was above or equal to 0.3,one patient's visual acuity was under 0.05,4 patients' visual acuity was between 0.05 and 0.3.Conclusion Brachytherapy was an effective option for the treatment of choroidal metastasis.%目的 观察脉络膜转移癌患者短程放射治疗的临床效果.方法 回顾性系列病例研究.收集2004年2月至2012年9月北京大学人民医院眼科中心接受钌106放射敷贴器短程放射治疗的22例(23只眼)脉络膜转移癌的患者的临床资料,观察分析眼肿瘤控制情况(瘤体体积变化及视网膜下液吸收情况)、眼球保留率以及治疗后视力.结果 22例患者就诊时年龄最小31岁,最大74岁,年龄中位数为59岁.男性10例,女性12例.22例患者中,18例患者(18只肿瘤眼)有治疗后1次或以上的随诊记录,观察期1 ～ 72个月,中位数为13个月.18只肿瘤眼在接受治疗后均可观察到明显的肿瘤缩小和视网膜下液吸收,经治疗后眼球均得以保存,治疗后视力:≥0.3者13只眼,占72.22％;≥0.05且＜0.3者4只眼,占22.22％;＜0.05者1只眼,占5.56％,明显优于治疗前视力.结论 钌106放射敷贴器对脉络膜转移癌的治疗有一定的效果.