新鲜羊膜与生物羊膜覆盖治疗早期重度眼表烧伤的疗效比较

摘要

目的 比较新鲜羊膜与生物羊膜治疗严重眼表烧伤的效果.方法 重度眼表烧伤34例(39眼).随机分为新鲜羊膜组18例(20眼),生物羊膜组16例(19眼).术后随访4～ 10个月,平均(6.2±1.8)个月,观察两组临床疗效.结果 新鲜羊膜组未见植片早期脱落,3眼行二次手术,生物羊膜组出现2眼羊膜脱落,9眼行二次手术,两组需二次手术率差别有统计学意义(P＜0.05)；角膜斑翳、白斑及角膜新生血管发生差别无统计学意义(P＞0.05).结论 新鲜羊膜与生物羊膜在严重眼表烧伤覆盖治疗均能有效重建眼表.新鲜羊膜疗效优于生物羊膜.%Objective To compare the therapeutic effect of fresh amnion and biological amnion covering for severe ocular surface bum.Methods 34 patients 39 eyes with serious ocular surface bum were randomly divided into fresh amnion 18 cases(20 eyes) and biological amnion 16 cases(19 eyes).All cases were followed up for 4 ～ 10 months at average (6.2 ± 1.8) months after surgery to observe the clinical effects.Results There were no eye with early amnion loss and 3 eyes with second surgery in fresh amnion group.There were 2 eyes with early amnion loss and 9 eyes with second surgery in biological amnion group.The second surgery rate of both groups had significant difference (P ＜ 0.05).The incidence of corneal macula,corneal leucoma and corneal neovascularization had no significant difference(P ＞ 0.05).Conclusion The fresh amnion and biological amnion may be effective and valuable in the ocular surface reconstruction.The therapeutic effect of fresh amnion is better than biological amnion.