血脂紊乱与糖尿病视网膜病变相关性研究现状与进展

摘要

Dyslipidemia plays an important role in the pathogenesis of diabetic retinopathy (DR).A preliminary study found that low-density lipoprotein cholesterol,apolipoprotein (Apo) B and Apo B / Apo A1 ratio were positively correlated with DR,while high-density lipoprotein cholesterol,Apo A1 was negatively correlated with DR and proliferative DR.Reducing the blood fats to be helpful to DR control.However,the mechanism of hyperlipidemia in the pathogenesis of DR,the reason of dyslipidemia in diabetic patients and the interaction between hyperglycemia and hyperlipidemia in DR are not clear yet.Moreover,there is no predictive indicators related to blood lipid for DR.Understanding the relationship between dyslipidemia and DR can provide definite evidence for fat-reducing therapy for DR control.%血脂紊乱在糖尿病视网膜病变(DR)发生发展中发挥重要作用.初步研究发现低密度脂蛋白胆固醇、载脂蛋白(Apo)B及Apo B/Apo A1比值与DR呈正相关,高密度脂蛋白胆固醇、Apo A1与DR、增生型DR呈负相关.降低血脂有助于DR的临床防治.但目前关于高血脂在DR发病中的作用机制、糖尿病患者血脂紊乱的原因以及高血糖与高血脂在DR中的相互作用均未完全明确,且临床上尚缺乏基于血脂的DR发生发展的预测指标.深入了解血脂紊乱与DR的相关性有助于临床以降脂为靶点防治DR提供参考依据.