Objective To investigate the effects of different gargling methods of sodium bicarbonate on oral pH values in children with malignant tumors undergoing chemotherapy, and to provide references for preventing oral fungal infection. Methods Totally 36 children with malignant tumors were recruited as research objects. Gargling methods were designed based on different sodium bicarbonate concentration, rinsing time, rinsing volume, and rinsing bites. Oral pH value was tested by pH indicator strips before and after rinsing. Results Sodium bicarbon-ate solution concentration, rinsing volume, ringing time and rinsing bites all influenced the changes of oral pH val-ue after rinsing. Regardless of methods, oral pH value was restored to the level of pre-rinse after 90 minutes. There were no significant differences in degree of comfort and compliance among different methods. Conclusion For children with malignant tumors undergoing chemotherapy, 5% 15ml sodium bicarbonate gargle is recommended to be rinsed for 30 seconds with 3 mouthfuls, and the interval is recommended to be no more than 90 minutes.%目的 了解恶性肿瘤化疗患儿采用碳酸氢钠溶液不同漱口方案漱口后口腔pH值的变化情况,为临床预防恶性肿瘤化疗患儿口腔真菌感染提供科学依据.方法 以36例恶性肿瘤化疗患儿为研究对象,设计溶液浓度、含漱量、含漱时间与连漱口数不同的碳酸氢钠溶液漱口方案,采用pH值试纸测定漱口前与漱口后各个时间点患儿口腔的pH值,分析不同漱口方案对口腔pH值的影响与变化趋势.结果 碳酸氢钠溶液浓度、含漱量、含漱时间与连漱口数等均影响漱口后口腔pH值的变化.口腔pH值均在漱口后90 min恢复至漱口前水平,不受漱口方法影响.采用不同方法漱口时患儿舒适度与依从性无明显差异.结论 采用5%碳酸氢钠溶液15 ml、含漱30 s、连漱3口、每90 min漱口1次的漱口方案,恶性肿瘤化疗患儿漱口后口腔pH值碱化更明显,有利于预防口腔真菌感染.
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