慢性心力衰竭患者 hs-CRP BNP Hcy 水平变化及临床意义

摘要

目的：探讨慢性心力衰竭（CHF）患者高敏C-反应蛋白（hs-CRP）、B型脑钠肽（BNP）、同型半胱氨酸（ Hcy）水平变化及临床意义。方法测定63例CHF患者（ CHF组）以及55名健康体检者（对照组） hs-CRP、BNP、Hcy水平及左室射血分数（ LVEF）值，比较两组间各项指标差异，并分析指标间的相关性。结果与对照组相比较，CHF组患者hs-CRP、BNP、Hcy水平均明显增高（P＜0.05）；随着心功能分级的增高，CHF患者hs-CRP、BNP、Hcy水平也随着不断升高（ P＜0.05）；CHF患者hs-CRP、BNP、Hcy水平与LVEF值呈明显负相关（ P＜0.05）。结论 hs-CRP、BNP、Hcy水平与CHF患者心衰严重程度密切相关，且与患者LVEF具有良好的相关性，可作为评价CHF患者左室功能的辅助指标。%Objective To investigate changes of the levels of hs-CRP, BNP and Hcy and their clinical sig-nificances in patients with chronic heart failure (CHF).Methods The levels of hs-CRP, BNP, Hcy and LVEF in 63 patients with CHF(CHF group) and 55 healthy people(control group) were analyzed.The changes of hs-CRP, BNP, Hcy and LVEF were compared between the two groups .The relationship between hs-CRP, BNP, Hcy and LVEF was analyzed .Results Compared with the control group , the levels of hs-CRP, BNP and Hcy in CHF group were signigi-cantly higher(P<0.05).The individuals with higher levels of hs-CRP, BNP and Hcy had higher NYHA cadiac function classification in the CHF group(P<0.05).The levels of Hs-CRP, BNP and Hcy were positively correlated with LVEF(P<0.05).Conclusion The levels of hs-CRP, BNP and Hcy in patients with CHF are positively corre-lated with the aggravation of heart failure , and are positively correlated with LVEF , which can be used as the ancillar-y diagnosis of chronic heart failure .