Objective To discuss the characteristics and function of the Wnt signal transduction way and the N-cadherin/(}-catenin compound in the tumorigenesis and migration of brain glioma. Methods The expressions of |J-catenin and N-cadherin in glioma samples of different grades and normal brain tissues were detected by immunohistochemistiy and Western blot. Results ($-catenin was expressed in glioma cells and the expression level was higher in high grade glioma than that of poor grade glioma (P = 0.015) and normal brain tissues (P =0.001). The expression level of N-cadherin was lower in high grade glioma than that of poor grade glioma (P =0.007), but there was no significant difference in N-cadherin expression between normal brain tissues and poor grade glioma (P = 0. 124). Conclusion Wnt signaling transduction way and N-cadherin/1$-catenin is probably involved in the tumorigenesis and differentiation.%目的 探讨Wnt信号转导途径及N-cadherin/β-catenin复合物在脑胶质瘤发生及迁移中的特性和作用.方法 利用免疫组化及Western blot方法检测各级别脑胶质瘤标本及正常对照脑组织中β-catenin及N-cadherin的表达.结果 临床各级脑胶质瘤病理组织中存在β-catenin的表达,而且高级别胶质瘤中表达水平明显高于低级别胶质瘤(P=0.015)和正常组织(P=0.001).N-cadherin在高级别胶质瘤中的表达水平明显低于低级别胶质瘤(P=0.007),但在正常脑组织和星型细胞瘤则没有明显差异(P=0.124).结论 经典的Wnt信号转导途径可能在胶质瘤的发生发展中存在作用,N -cadherin/β-catenin复合物调节障碍可能参与了胶质瘤迁移过程.
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