帕金森病患者僵直迟缓症状神经元电活动特点研究

摘要

Objective This study aims to explore the neuronal activity in the subthalamic nucleus in patients with akinetic-rigid-type Parkinson(s) disease (PD).Methods A total of 25 akinetic-rigid type PD patients underwent bilateral implantation of an electrode for subthalamic nucleus (STN) deep brain stimulation (DBS).Microelectrode recordings were performed in the STN during surgery and the neuronal activity was analyzed offline.Neuronal spike trains were extracted and their spectral characteristics were calculated.Results Of 180 neurons obtained from akinetic-rigid type PD patients,64 (35.6％) neurons showed significant oscillatory activity with beta frequency.Conclusion Beta frequency neuronal discharge in STN are likely responsible for akinetic-rigid signs.%目的 探讨帕金森病(PD)患者僵直迟缓症状的神经元电活动特点.方法 25例僵直迟缓为主征的PD患者接受立体定向丘脑底核(STN)脑深部电极植入术(DBS).术中通过微电极记录技术采集神经元电活动.应用单细胞分析方法,峰间隔分析方法分析神经元放电的频率和形式,应用功率谱分析方法分析神经元放电周期节律.结果 分析了180个信号稳定的神经元,平均放电频率为(40.6±22.3) Hz;有35.6％ (n =64)神经元有周期节律性放电,放电周期节律在β节律内.结论 β节律的神经元周期节律性电活动可能和PD僵直迟缓症状的病理生理改变有关.