Objective CT and MRI manifestations after the multi-targets lesioning for the treatment resistant schizophrenia were analyzed in order to improve the understanding of craniocerebral changes after multiple-targets lesions.Methods A total of 50 cases of treatment resistant schizophrenic treated with multiple-targets lesions were collected and CT and MRI were performed.Results A total of 255 lesions were found in 50 patients,which were the multi-symmetry distributed in the amygdala,the anterior extremity of the capsule and the cingulate cortex,where 60.8％ (155/255) were round in shape,29.8％ (76/255) were the short stripes,7.8％ (20/255) were the flaky irregular,and 1.6％ (4/255) were small point.Conclusion CT and MRI manifestations after the multi-targets lesioning for the treatment resistant schizophrenia are characteristic,and correct diagnosis can be made in combination with the clinical manifestations and medical history.%目的 分析难治性精神分裂症多靶点联合毁损术后计算机断层扫描(CT)及磁共振成像(MRI)表现,提高对多靶点联合毁损术后颅脑改变的认识.方法 收集我院经多靶点联合毁损术治疗的难治性精神分裂症患者50例,进行头颅CT及MRI检查.结果 50例患者共发现毁损灶255处,多对称性分布于杏仁核、内囊前肢及扣带回,其中类圆形者为60.8％(155/255);短条状为29.8％(76/255);片状不规则为7.8％(20/255),小点状1.6％ (4/255).结论 难治性精神分裂症多靶点联合毁损手术治疗后影像学具有典型的特点,在诊断过程中应密切结合临床及相关病史.
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