白细胞介素6基因多态性与动脉粥样硬化性脑梗死的关系

摘要

Objective To investigate whether IL-6-572C/G polymorphism is associated with atherosclerotic cerebral infarction (ACl) in a Han population in Hunan Province. Methods The distributions of allele and genotype frequencies of 572C/G polymorphism of IL-6 gene were examined in 199 patients with ACI and 196 healthy controls using Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results There was significant difference in genotype of 572C/G polymorphism between ACI patients and controls ( x2 = 5.120, P ＜ 0.05 ). There was significant difference in frequencies of allele of 572C/G polymorphism between ACI patients and controls( frequencies of C and G allele,ACl group :0.741, O.259 VS control group: 0.816、0.184 )( x2 = 5.491, P ＜0.05 ). Logistic regression analysis showed that polymorphism GG genotype of the IL-6 gene -572C/G polymorphism was associated with ACI ( OR = 3.216,95 ％ CI:1.145 -6.732). Conclusions Homozygous GG genotype of IL-6 gene -572C/G polymorphism may be one of the predisposing genes of ACI in a Hah population in Hunan province.%目的 探讨IL-6-572C/G基因多态性与中国湖南地区汉族人群动脉粥样硬化性脑梗死(atherosclerotic cerebral infarction,ACI)的关系.方法 在湖南汉族人群中筛选199例脑梗死患者为脑梗死组,196名健康体检者为对照组,采用聚合酶链反应-限制性片段长度多态性(polymerase chain reaction -restriction fragment length polymorphism,PCR-RFLP)方法测定IL-6-572C/G基因多态性.结果 脑梗死组与对照组间比较,IL-6-572C/G基因型分布存在统计学差异 ( χ 2=5.120,P＜0.05),IL-6 -572C/G基因C和G等位基因频率也存在统计学差异,(C和G等位基因频率,脑梗死组为0.741、0.259,对照组为.0.816、0.184)( χ 2=5.491,P＜0.05).G等位基因携带者发生脑梗死的风险是C等位基因的1.552倍( OR=1.552,95.%CI:1.092-2.315).结论 IL-6-572C/G基因多态性与ACI发病有关,可能是中国湖南地区汉族人群ACI发病的遗传易感基因.