雌激素替代疗法与女性阿尔茨海默病关系的Meta分析

摘要

Objective To investigate the relationship between estrogen replacement therapy and female patients with Alzheimer's risk. Methods We searched the PubMed, Springer, CBM, CNKI, VIP database for studies on the es-trogen replacement therapy and women with Alzheimer's disease, retrieval time from database to 2012 December. We evaluated the methodological quality of the included studies, used RevMan 5.0 software to analyze the extracted data. Results We found seven case-control studies which included 1392 patients and 2719 controls. The meta analysis re-sults show that the proportion of estrogen replacement therapy in AD group is significantly lower than that of the con-trol group, the difference has statistically significant [OR=0.68, 95%CI(0.50,0.90), P=0.01]. Conclusions estrogen re-placement therapy has effects on female patients with Alzheimer's disease, and is a protective factor.%目的：探讨雌激素替代疗法与女性阿尔茨海默病发病风险之间的关系。方法计算机检索PubMed、Springer、CBM、CNKI和维普数据库，查找雌激素替代疗法与女性阿尔茨海默病相关性的病例对照研究，检索时间从建库到2012年12月。评价纳入文献的方法学质量后，采用RevMan 5.0软件对提取的数据进行分析。结果共纳入7项病例对照研究，病例组1392例，对照组2719例。Meta分析结果显示AD组中雌激素替代疗法者所占比例明显低于对照组，差异有统计学意义[OR=0.68，95%CI（0.50，0.90），P=0.01]。结论雌激素替代疗法对女性阿尔茨海默病存在影响，且为保护因素。