高压氧对脑梗死患者同型半胱氨酸、高敏C反应蛋白和D-二聚体的影响

摘要

Objective To observe the contents of homocysteine (Hcy),C-reactive protein (hsCRP) and D-dimer(DD) in patients with cerebral infarction and the effects of hyperbaric oxygen (HBO) on them.Methods One hundred and twenty cases of cerebral infarction were voluntarily divided into 2 groups,the control group and the therapy group,each consisting of 60 cases.The patients of the control group received drug treatment,while the therapy group received HBO treatment in addition to routine drug treatment.The levels of Hcy,hsCRP and DD in the patients of the 2 groups were measured both before and after therapy,and changes in neurological functional defect (NFD) were also evaluated both before and after treatment.Results For both groups,the levels of Hcy,hsCRP and DD before therapy were higher than the normal reference value,and they all significantly decreased following therapy (P ＜ 0.01).When compared with those of the control group,the levels of Hcy,hsCRP and DD all decreased significantly (P ＜ 0.05 or P ＜ 0.01).The NFD in the patients of both group were decreased after therapy(P ＜ 0.01),with the NFD decreased more significantly in the patients of the therapy group (P ＜ 0.01).Conclusions HBO therapy could obviously reduced the levels of Hcy,hsCRP and DD in patients with cerebral infarction,which might be beneficial to the recovery of patients with cerebral infarction.%目的 观察脑梗死患者血清同型半胱氨酸(Hcy)、高敏C反应蛋白(hsCRP)和血浆D-二聚体(DD)的含量及高压氧(HBO)对这些指标的影响.方法 经患者知情同意及医院伦理委员会批准后,将120例脑梗死患者按照自愿原则分为治疗组和对照组,每组60例.对照组和治疗组患者分别给予药物治疗和药物加HBO治疗.测定治疗前后患者Hcy、hsCRP和DD含量,并观察2组患者治疗前后神经功能缺损评分(NDF)的变化.结果 治疗前2组患者的Hcy、hsCRP和DD的测定值均明显高于正常范围,经过治疗后均明显下降(P＜0.01);与对照组相比,治疗组Hcy、hsCRP和DD含量下降明显(P＜0.05或P＜0.01).治疗后2组患者的NDF较治疗前均明显下降(P＜0.01),而治疗组下降更明显(P＜0.01).结论 HBO治疗可以明显降低脑梗死患者Hcy、hsCRP和DD的含量,有利于脑梗死患者康复.