雄激素与阿尔茨海默病的研究进展

摘要

阿尔茨海默病(AD)是以进行性记忆力减退、认知功能障碍、人格改变等为特征的神经系统退行性疾病.在基础研究及临床调查中发现,AD患者的血清睾酮水平较正常老年男性显著降低,从而引起人们对雄激素与AD关系的研究.本文结合国内外近几年研究,就雄激素与阿尔茨海默病的关系以及相关的作用通路和作用机制进行阐述.%Alzheimer's disease (AD) is an age-related neurological disease that is the leading cause of dementia, characterized by gradual decline of memory, cognitive dysfunction and personality disorder. Epidemiological studies and animal studies have found that low circulating levels of androgen is a risk factor for AD. In this paper, we reviewed the relationship between androgen and AD and the related mechanism.