β-羟基-β-甲基丁酸治疗肌少症的临床研究现状

摘要

Sarcopenia is a common disease in the elderly,which increases the risks of falls,disability,and all-causes mortality in them.β-hydroxy-β-methylbutyrate(HMB), as a metabolite of leucine, has been proven to increase muscle protein synthesis and decrease muscle breakdown,and shows anti-inflammatory effect.As a kind of nutritional supplement for sarcopenia,HMB has recently been reported to improve muscle mass,muscle strength and body function to some extent.This review summarized the recent clinical researches of HMB for sarcopenia.%肌少症是一种常见的老年疾病,会增加老年人发生跌倒、衰弱的风险,增加全因死亡率.β-羟基-β-甲基丁酸(HMB)作为亮氨酸的代谢产物,已证实可以增加肌肉合成、减少肌肉分解,并且具有抗炎作用,是肌少症营养干预的方法之一,对于改善肌肉质量、肌肉力量和躯体功能具有一定作用.本文综述了近年来HMB治疗肌少症的临床研究进展.