目的 探讨直肠癌患者术后发生应激性溃疡出血的影响因素.方法 回顾性分析2002年1月～ 2012年3月于我院诊治并行手术治疗的468例直肠癌患者病历资料.结果 术后发生应激性溃疡出血病例18例,发生率为3.85％；单因素分析显示高龄、男性、饮酒史、肿瘤发生淋巴结转移、手术时间长、术后发生其他并发症、术后前白蛋白下降等因素与直肠癌患者术后发生应激性溃疡出血明显相关(P＜0.05)；非条件多因素Logistic分析结果显示高龄、淋巴结转移、手术时间长、术后并发症发生、术后血清前白蛋白下降是直肠癌患者术后发生应激性溃疡出血的独立危险因素(P＜0.05).结论 直肠癌患者术后发生应激性溃疡出血较为常见,男性饮酒患者直肠癌患者术后发生应激性溃疡出血的可能性明显增加,高龄、肿瘤淋巴结转移、手术时间长、术后并发症发生、术后血清前白蛋白下降等因素可作为直肠癌患者术后应激性溃疡出血发生的独立危险因素.%Objective To explore the influence factors of postopeartive digestive hemorrhage caused by stress ulcer in the patients of rectal cancer. Method Clinical data of 468 rectal cancer patients treated with surgery during January 2002 to March 2012 were retrospectively analyzed. Results There werel8 cases suffered from the postoperative digestive hemorrhage caused by stress ulcer with the incidence of 3. 85%. The single factor analysis showed old, male, alcohol consumption, lymph node metastasis, long operation, postoperative complications and decline in prealbumin were related with the hemorrhage of stress ulcers ( P < 0.05 ) . Unconditional Logistic analysis also showed those factors were risk factors ( P < 0. 05 ) except the gender and the alcohol consumption. Conclusions The postoperative digestive hemorrhage of stress ulcer in the patients with rectal cancer is common. Male and alcohol consumption play an important role in its pathogenesis, and the lymph node metastasis, long operation, postoperative complications and decline in prealbumin are its independent risk factors.
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