Objective To observe the clinical efficacy of cynanchum corymbosum liquid for radiation skin injury in nasopharyngeal carcinoma patients. Methods A total of 62 patients with nasopharyngeal carcinoma treated with linear accelerator radiotherapy in the Radiotherapy Department of Lishui People's Hospital of Zhejiang Province from July 2014 to June 2015 were randomly divided into observation group (n=30) and control group (n=32) according to the order of admission. Other 60 patients with nasopharyngeal carcinoma treated with Synergy high energy X-ray radiotherapy from July 2015 to June 2016 were randomly divided into observation group (n=30) and control group (n=30). The patients in control group were given routine skin nursing guidance, the observation group were given cynanchum corymbosum liquid to prevent radiation dermatitis based on the control group methods. The occurrence time, cumulative amount and severity of radiation skin injury were observed in the two groups. Results The incidences of skin injury in the observation group of patients treated with linear accelerator radiotherapy were 18 cases, 20 cases and 3 cases respectively in the Ⅰ, Ⅱ, Ⅲdegrees, which were significantly lower than those in the control group (Z=-2.967, P< 0.01). The average cumulative radiation amount were (46.0±4.0), (66.0±2.0) and (68.0±2.0) Gy respectively, which were all greater than those of the control group (t=9.320, 15.445, 8.921; P< 0.01). The incidences of skin injury in the observation group of patients treated with Synergy high energy X-ray radiotherapy were 28 cases and 2 cases respectively in the Ⅰ, Ⅱdegrees, which were significantly lower than those in the control group (Z=-2.967, P< 0.01). The average cumulative radiation amount were (55.2±2.3) Gy and (64.4±2.3) Gy respectively,which were greater than those of the control group (t=17.614, 2.820; P<0.01). Conclusions The cynanchum corymbosum liquid can effectively prevent radiation skin injury in nasopharyngeal carcinoma patients and guarantee the the successful implementation of radiotherapy.%目的观察畲药刺瓜液用于防治鼻咽癌患者放射性皮肤损伤的临床疗效.方法将浙江省丽水市人民医院放疗科2014年7月—2015年6月收治的62例接受直线加速器放射治疗的鼻咽癌患者按入院顺序随机分为观察组30例和对照组32例;2015年7月—2016年6月收治的60例接受医科达Synergy高能X射线调强放射治疗的鼻咽癌患者按入院顺序随机分为观察组30例和对照组30例.对照组进行常规皮肤护理指导,在对照组基础上观察组放疗开始时即给予照射野皮肤畲药刺瓜液涂擦.观察两组患者首次放射性皮肤损伤发生的时间、累积辐射剂量与皮肤损伤程度.结果采用直线加速器照射患者观察组皮肤损伤发生的程度Ⅰ、Ⅱ、Ⅲ度分别为18、20、2例,低于对照组(Z=-2.967,P<0.01);平均累积辐射剂量分别为(46.0±4.0)、(66.0±2.0)、(68.0±2.0)Gy,高于对照组(t值分别为9.320、15.445、8.921;P<0.01).采用高能X射线调强放疗患者观察组皮损严重程度Ⅰ、Ⅱ度分别为28、2例,低于对照组(Z=-2.921,P<0.01);平均累积辐射剂量分别为(55.2±2.3)、(64.4±2.3)Gy,均高于对照组(t值分别为17.614、2.820;P<0.01).结论畲药刺瓜液能有效防治鼻咽癌患者放射性皮肤损伤,保证了患者放疗的顺利实施.
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