血清降钙素原检测对细菌性感染诊断的临床意义研究

摘要

Objective To investigate clinical significance of serum procalcitonin for diagnosis of bacterial infection.Methods A total of 90 patients were divided by ACCP/SCCM consensus conference and clinical related manifestations into septicopyemia group, localized bacterial infection group and asymptomatic control group, with 30 cases in each group, and they all received serum procalcitonin detection. Comparison was made on serum procalcitonin levels in different time of the three groups.Results Septicopyemia group had higher serum procalcitonin level during admission than the other two groups (P<0.05). After 24 h of drug administration and 5, 9 d after admission, septicopyemia group had lower serum procalcitonin level than that during admission (P<0.05).Conclusion As an indicator for early diagnosis of systemic bacterial infection, serum procalcitonin can reveal progress of septicopyemia by its dynamic change, which is the objective reference for medical judgment.%目的：探讨血清降钙素原对细菌性感染诊断的临床意义。方法90例患者，根据ACCP/SCCM共识会议及临床相关表现分为脓毒血症组、局部细菌感染组和无症状的对照组，各30例，均进行血清降钙素原测定，比较三组不同时间血清降钙素原的水平。结果脓毒血症组入院时血清降钙素原水平高于其他两组(P<0.05)；脓毒血症组用药24 h及住院5、9 d后血清降钙素原水平低于入院时(P<0.05)。结论血清降钙素原可以作为全身细菌感染的早期诊断指标，其动态变化可以反映脓毒血症患者的病情进展情况，是医生判断病情的客观依据。