血液透析和腹膜透析对男性肾性贫血患者睾酮水平和贫血状态的影响

摘要

目的:分析血液透析 (HD) 和腹膜透析 (PD) 对不同时间终末期肾脏病 (ESRD) 患者睾酮和肾性贫血的影响.方法:2015-01-01—2016-12-31在本院进行透析治疗患者64例, 按其透析方式分为HD组和PD组, 各32例, 分别比较两组患者透析前、透析3个月、透析6个月后血清总睾酮、游离睾酮和透析前、透析6个月后血红蛋白 (Hb) 、红细胞计数 (RBC) 、红细胞比容 (Hct) 水平变化.结果:透析前两组患者总睾酮、游离睾酮、Hb、RBC、Hct水平均无统计学差异 (P>0.05), 随着透龄增加, PD组患者总睾酮、游离睾酮逐渐增加, PD 3—6个月后显著高于HD组;PD 6个月后患者贫血状态得到有效纠正, 其Hb、RBC、Hct升高, 明显优于HD组 (P<0.05) .结论:PD 3个月可明显升高男性ESRD患者血清睾酮水平, 纠正肾性贫血, 效果优于HD.%Objective: To analyze the effects of hemodialysis (HD) and peritoneal dialysis (PD) on testosterone and renal anemia in patients with end-stage renal disease (ESRD) .Method: 64 patients were treated with dialysis in our hospital from 2015-01-01 to 2016-12-31. They were divided into HD group and PD group, 32 cases in each group. The levels of serum total testosterone and free testosterone were compared before dialysis, 3 months after dialysis and 6 months after dialysis.The levels of hemoglobin (HB), red blood cell count (RBC) and hematocrit (Hct) were measured before and 6 months after dialysis. Results: There was no significant difference in total testosterone, free testosterone, HB, RBC and Hct between the two groups before dialysis. With the increase of dialysis age, total testosterone and free testosterone in PD group increased gradually, and were significantly higher than those in HD group after 3-6 months. At the same time, anemia of PD patients was effectively corrected after 6 months, and the levels of HB, RBC and Hct were significantly higher than those of HD group (P<0.05) . Conclusion: PD for 3 months can significantly increase the serum testosterone level in male ESRD patients and correct renal anemia. The effect is better than HD.