Objective: To understand the change of total red blood cells(RBCs) in a simulation of microcirculation during the myocardial ischaemia. Methods: The simulation system of capillary blood vessels by silicon microchannels was set up, and the deformability of total RBCs was measured in this system. Results: Compared with the control group, the filtration index(IF), filtration resistance(β) and block probability(ε) in the angina pectoris group increased significantly( P < 0.01 ). Moreover, the temporal parameters of a single cell passing through the microchannels(the time for entering the pore, the time for exiting the pore, the total passage time) also increased markedly. Conclusion: The results indicate that during the myocardial ischaemia, the stiffness and resistance of the RBCs increase, the movement velocity of the RBCs decrease, and the block probability of the RBCs increase in a simulation system of microcirculation.
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