谷氨酸脱羧酶抗体在2型糖尿病患者中的检出率及分布特征

摘要

Objective: To explore the change of detection rate and distribution feature of glutamic acid decarboxylase antibody (GAD-Ab) in patients with type 2 diabetes mellitus (T2DM). Method: To detect the positive rate of GAD-Ab using EL1SA method in 1970 patients with T2DM and its distribution in different sex, age, course of disease and body mass index (BM1). Fasting, postprandial insulin 2H (FINS, 2hLNS) and fasting, postprandial 2h C peptide (FCP, 2hCP) level were detected by electro-chemiluminescence in GAD-Ab positive and negative patients and compared with the healthy people. Results: 126 cases were GAD-Ab positive among the 1970 patients with T2DM and the total positive rate was 6. 39%. GAD-Ab was mainly distributed in patients during the 30 ~49 years old (P<0. 05) and with low body mass index (P<0. 05) , but the positive rate had no significant difference (P<0. 05) among different courses of disease. FINS,2hINS,FCP and 2hCP were lower in GAD-Ab positive patients than those in GAD-Ab negative patients and healthy people (P<0. 05). Conclusion: The GAD-Ab test is helpful to the diagnosis and evaluation of insulin function of patients with T2DM.%目的:观察谷氨酸脱羧酶抗体(GAD-Ab)在2型糖尿病(T2DM)患者中的检出率和分布特征.方法:采用ELISA检测1 970例T2DM患者的GAD-Ab总检出率及GAD-Ab在不同性别、年龄、病程和体重指数(BMI)中的分布情况;用电化学发光法检测GAD-Ab阳性和阴性T2DM患者的空腹、餐后2h胰岛素(FINS、2hINS)和空腹、餐后2h C肽(FCP、2hCP)水平,并与健康人群比较.结果:1 970例T2DM患者GAD-Ab阳性126例,总检出率为6.39%,GAD-Ab阳性主要分布在30~39岁年龄组(P<0.05),低BMI组检出率较高(P<0.05),不同病程组检出率无明显差异(P>0.05).GAD-Ab阳性组T2DM FINS、2hINS、FCP和2hCP均低于GAD-Ab阴性组和健康对照组(P<0.05).结论:GAD-Ab检测有助于临床对T2DM患者胰岛素功能变化进行评价.