颈内动脉狭窄患者核磁共振灌注加权成像与血管性认知功能障碍的相关性分析

摘要

Objective To explore relationship between magnetic resonance perfusion weighted imaging (PWI) and cognitive function following internal carotid artery stenosis. Method 92 patients with unilateral severe internal carotid artery stenosis were analyzed retrospectively in our hospital from January 2014 to March 2017. The patients were divided into either a mild perfusion injury group (n=55) or a sever perfusion injury group (n=37) according to the PWI. Mini-mental state examination (MMSE) and Montreal cognitive assessment (MOCA) were measured. Analyzed the relationship between perfusion injury and cognitive function. Result Mild perfusion injury group included 55 cases, sever perfusion injury group included 37 cases. The levels of MMSE (P=0.024) and MOCA (P=0.017) in the mild perfusion injury group were higher than those in the sever perfusion injury group.The results of multivariate Logistic regression analysis revealed that there were independent correlation between MMSE (OR=1.901, P=0.021) and MOCA (OR=2.119, P=0.009) and PWI. Conclusion There were independent correlation between PWI and cognitive function following internal carotid artery stenosis.%目的 探讨颈内动脉狭窄患者核磁共振灌注加权成像(magnetic resonance perfusion weighted imaging,PWI)与血管性认知功能障碍(vascular cognitive impairment,VCI)的相关性.方法 回顾性分析2014年1月至2017年3月本院收治的单侧颈内动脉重度狭窄患者92例,依据核磁灌注结果分为轻度灌注损伤组和重度灌注损伤组;入院后使用简易精神状态量表(mini-mental state examination,MMSE)和蒙特利尔认知评价量表(Montreal cognitive assessment,MOCA)进行评价,分析VCI与灌注损伤的关系.结果 轻度灌注损伤组55例,重度灌注损伤组37例;轻度灌注损伤组的MMSE评分和MOCA评分明显高于重度灌注损伤组,差异有显著性(P=0.024、0.017).Logistic回归分析显示,两组间MMSE评分(OR=1.901,P=0.021)和MOCA评分(OR=2.119,P=0.009),差异有显著性.结论 颈内动脉狭窄患者PWI与VCI之间具有独立相关性.