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中国结合医学杂志：英文版

中国结合医学杂志：英文版

本刊主要宣传党的中医政策和中西医结合方针，报道我国中西医结合在临床、科研、预防、教学等方面的经验和成果，探讨中西医结合的思路和方法，介绍国内外有关本专业的进展，开展学术讨论，为提高西医结合水平、继承和发扬我国传统的医药学、促进我国医学科学现代化服务。
  • 发文量：2858
  • 被引量：1169
  • H指数：8
  • 开始收录时间：1995(1)
  • CNKI综合因子：1.071
  • 维普期刊影响因子： 1.065
  • 万方期刊影响因子：1.0
  • 创刊时间：1995
  • 国内刊号/CN：11-4928/R
    国际刊号/ISSN：1672-0415
  • 发行周期：月刊
    邮发代号：82-825
  • 主管单位：
    主办单位：中国中西医结合学会;中国中医科学院
中国结合医学杂志：英文版-联系信息
  • 主编：陈可冀
  • 电话：010-62877592
  • 邮箱：cjim_en@cjim.cn
  • 地址：北京西苑草场1号
  • 邮编：100091
中国结合医学杂志：英文版-获奖情况
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中国结合医学杂志：英文版 >2023年第12期

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  • 摘要：Objective:To investigate the effects of ursolic acid(UA) on T-cell proliferation and activation,as well as to examine its effect on nuclear factor-κB(NF-κB) signaling pathway in T cells.Methods:T-cells isolated from BALB/c mice were incubated with UA at concentrations ranging from 5-30μmol/L in the presence of phorbol 12-myristate 13-acetate(PMA) or PMA plus ionomycin.The proliferation of T cells was measured by the MTT assay.The expressions of CD69,CD25,and CD71 on T-cell surface were analyzed using flow cytometry. The level of interleukin-2(IL-2) in the culture supernatant of activated T cells was quantified by enzyme-linked immunosorbent assay(ELISA).The level of phosphorylated IκB-α(p-lκB-α) in total protein and p65,a subunit of NF-κB,nuclear translocation were measured by Western blot analysis.Results:UA in a dose-dependent manner significantly decreased the proliferation and inhibited the surface expressions of CD69,CD25,and CD71 in murine T lymphocytes upon in vitro activation(P<0.01).Significant reduction of IL-2 production was found in activated T cells treated with UA(P<0.01).The PMA-induced increase in p-lκB-αprotein was inhibited,and nuclear translocation of p65 from the cytoplasm was blocked by UA.Conclusion:UA is a potent inhibitor for T cell activation and proliferation;these effects are associated with the inhibition of NF-κB signaling pathway.
  • 摘要：Objective To evaluate the efficacy and safety of Yangyin Yiqi Huoxue Granule(养阴益气活血颗粒,YYHG)in the treatment of ischemic stroke(IS)patients with qi-yin deficiency and blood stasis syndrome(QYDBSS),and to explore its effective dosage.Methods The total of 288 patients were randomly assigned to the YYHG high-dose,YYHG low-dose,positive control(administered Xiaoshuantong Granule,XSTG,消栓通颗粒),or placebo control(administered inert granule)groups(72 cases per group)by software-drived competitive block randomization.The trial was conducted for a 28-day period,with a 180-day follow-up period.The primary outcome was the comprehensive curative evaluation,and secondary outcomes were the National Institute of Health Stroke Scale(NIHSS)score,Barthel activities of daily living(ADL)index score,the quality of life index(QLI)score,and the Chinese medicine syndrome(CMS)score.All analyses were done on an intention-to-treat basis.The clinical safety was also assessed.Results The total of 288 participants were recruited between June 1,2008 and September 30,2009,and 287 patients received intervention;the treatment groups were well balanced at baseline.The comprehensive cure rates of YYHG high-dose,low-dose,positive and placebo control groups were 63.38%,31.94%,36.11%and 6.14%,respectively;there was a statistical difference between the two groups(P<0.01),while the high-dose YYHG treatment group was significantly higher than the other 3 groups(P<0.01).The improvement of NIHSS,ADL,QLI and CMS scores of the YYHG high-dose and low-dose groups was significantly better than that of the positive control group and the placebo control group(P<0.05).In terms of improving the classification of the NIHSS scale and the assessment of the ADL scale,the YYHG high-dose group was significantly better than the other three groups(P<0.05),and the YYHG low-dose group was better than the placebo control group(P<0.01).At the same time,except for the QLI score,the high-dose group was better than the low-dose group(P<0.05).In terms of safety,adverse reactions after YYHG treatment were generally mild(3.78%),and no serious adverse reactions have been reported.Conclusion YYHG is safe and effective in the treatment of IS patients with QYDBSS.
  • 摘要：Objective:To investigate effects of Dahuang Zhechong Pill（大黄（?）虫,DHZCP） on the cell cycle and the related signal pathways in vascular smooth muscle cells（VSMCs） stimulated by platelet-derived growth factor（PDGF） with the method of serum pharmacology.Methods:DNA synthesis in VSMCs was examined by detecting 5’-bromo-2’-deoxyuridine incorporation with the immunocytochemical method.The cycle of VSMCs was evaluated with flow cytometry.Expressions of cyclin D1,p27,protein kinase Cα（PKCα）,and phosphorylated extracellular signal regulated kinase 1/2（ERK1/2） were quantified by Western blot method. Results:DHZCP containing serum significantly inhibited DNA synthesis of PDGF-stimulated VSMCs,arrested the cells in G1 phase,modulated the protein expressions of cyclin D1 and p27,and suppressed the activation of PKCαand ERK1/2.Conclusion:DHZCP containing serum inhibits VSMCs proliferation via modulating the expressions of cell cycle proteins to arrest the cell in G1 phase,which is attributed to,at least in part,suppressing PKCα-ERK1/2 signaling in VSMCs.
  • 摘要：Objectives:Lao Juan(LJ,劳倦) is a syndrome described in Chinese medicine(CM) that manifests with fatigue,fever,spontaneous sweating,indigestion,work-induced pain,weakness of the limbs,and shortness of breath.The present study was conducted to examine the reliability and validity of a Lao Juan Questionnaire(LJQ).Methods:A total of 151 outpatients and 73 normal subjects were asked to complete the LJQ.Seventy-tiiree normal subjects were additionally asked to complete the Chalder Fatigue Scale(CFS).Twelve clinicians determined whether the151 outpatients exhibited LJ or not.The internal consistency and construct validity for the LJQ were estimated using data from the outpatient subjects.The CFS data were used to examine the concurrent validity of the LJQ.Total LJQ scores and the clinicians' diagnoses of the outpatients were used to perform receiver operating characteristics(ROC)curve analyses and to define an optimum cut-off score for the LJQ.Results:The 19-item LJQ had satisfactory internal consistency(α=0.828) and concurrent validity,with significant correlations between the UQ and the CFS subscales.In the test of construct validity using principal component analysis,a total of six factors were extracted,and the overall variance explained by all factors was 59.5%.In ROC curve analyses,the sensitivity,specificity,and area under the curve were 76.0%,59.2%,and 0.709,respectively.The optimum cut-off score was defined as six points.Conclusions:Our results suggest that the LJQ is a reliable and valid instrument for evaluating LJ.
  • 摘要：Ｒｅｃｅｎｔ　Ｄｅｖｅｌｏｐｍｅｎｔ　ｏｆ　Ｔｒａｄｉｔｉｏｎａｌ　Ｃｈｉｎｅｓｅ　Ｍｅｄｉｃｉｎｅ　ｉｎ　Ｈｏｎｇ　ＫｏｎｇＭａｒｇａｒｅｔＣｈａｎ（ＤｅｐａｒｔｍｅｎｔｏｆＨｅａｌｔｈ，ＨｏｎｇＫｏｎｇＳｐｅｃｉａｌＡｄｍｉｎｉｓｔｒａｔｉｏｎＲ...
  • 摘要：目的将学习 Osmunda 装饰用的梨树 Thunb 的可能的 immunobiological 潜力。从 O 的根茎准备的乙醇摘录的方法 Immunomodulatory 效果。从摘录孤立的装饰用的梨树和酉分的混合物被调查在下面在里面用老鼠腹房间的 vitro 条件(2 污祬愠潬杮眠瑩 ? 牰来慮据 ? 瀠潲牧獥楳杮映潲 ? 牰来慮瑮搠祡? 摐 ?
  • 摘要：目的将在上皮的房间 B3 (HLE-B3 ) 由氢过氧化物(H2O2 ) 引起了的人的透镜对氧化损坏与雌激素的活动调查自然药用的单体 isopsoralen (ISR ) 的保护的效果并且追求保护的效果的可能的 mitochondrial proteomic 整齐。
  • 摘要：在关于互补、综合的药的临床的研究，尽管有终端用户的需要的不完全的理解，专家和科学家经常追求了一个研究议程。因而，以前的临床的试用的多数主要估计了干预的功效。欠缺的数据在他们的有效性上是可得到的。由产生比较最好的好处和伤害的证据支持决定制造者的比较有效性研究(CER ) 诺言在乎选择。这条证据，比证据可推广的更多由传统的使随机化的控制审判(RCT ) 产生了，更好被适合通知真实世界的照顾决定。CER 上的一个重音支持证据底的发展为临床并且政策决策。而在互补、综合的药的大多数区域比较有效性上的数据是少见的，可得到的针灸研究已经贡献 CER 证据。这篇论文将介绍 CER 并且为未来研究做建议。
  • 摘要：卷传播(vt ) 是发生在细胞外的液体(ECF ) 并且在大脑的脑髓的液体(CSF ) ， vt 信号经由导致散开和传送对流(流动) 的精力坡度从来源搬到目标房间的细胞间的通讯的一个普遍模式。， vt 隧道在配线传播(WT ) 是弥漫的在细胞外的空格形成丛隧道(轴突，终端) 是秘密的。速度是慢的(秒分钟) 在 vt 当时在在 WT 的毫秒范围快速。细胞外的空间是为 vt 的底层，它被细胞外的矩阵调制。Extrasynaptic vt 被连接到 synaptic 传播并且经常多半与到达 pre 的 extrasynaptic 领域的 synaptic 传输器由于不完全的散开障碍发生 -- 并且触处， astroglia，和甚至邻近的触处的 post-synaptic 膜。指示为多巴胺(DA ) 的 striatal 象 D2 一样调停受体的 extrasynaptic 形式的存在存在在在在人的 striatum 的 vivo 的本地电路水平的 vt。经由 vt 能在位于导致 Ca2+ 的 astroglia 的 extrasynaptic metabotropic glutamate 受体上扮演的 extrasynaptic 的 Synaptic glutamate 调停了 astrocytic glutamate 版本直到细胞外的空间(ECS ) 。长距离肽 vt 和 CSF vt 非常是有距离的主要长距离 vt 在 CSF 的 1 公里和流动。为贝它内啡肽和后叶催产素的长距离 vt 的指示被获得。我们建议在女大草原田鼠的单配偶可以通过后叶催产素 vt 的增加发生，特别在原子核 accumbens。在中央神经系统(CNS ) 从细胞的网络包含受体，蛋白质， RNA 和 mtDNA 进 ECF 和 CSF 的细胞外的泡的版本可以是在 CNS 的基本通讯。它代表体积传播的一种特殊形式， vt 的 Roamer 子类型。它可以极大地在蛋白质 conformational 混乱贡献 synaptic 粘性而且到病理学的蛋白质的传播的动态事件。vt 也发生在外部神经系统和联系房间。短、长的距离 vt 可以在空隙的液体经由散开和流动发生在顶点隧道。针灸能由免除传输器和调节的人神经终端和桅杆房间生产 vt 信号。
  • 摘要：Objective: To observe the effect of theo polyphenols(TP)on function of trans membranous signal of acute ischemic myocardium in rats. Methods: Model of myocardial ischemia was established. Thirty five male rats were randomly divided into 5 groups, 7 rats in each group. Non ischemic group:the anterior descending branch of left coronary artery was not ligated;Ischemic group:the time of ischemia continued for 10 min;TP groups:the groups were divided into 3 subgroups, TP dose was respectively 1 mg/kg, 4 mg/kg, 16 mg/kg, TP was administered through celiac injection 20 min before the anterior descending branch of left coronary artery was ligated. Results: The levels of phosphatidylinositol 4, 5 biphosphate(PIP 2), inositol 1, 4, 5 triphosphate(IP 3)in the ischemic group were markedly higher than those in the non ischemic group. The raise of the levels of PIP 2, IP 3caused by acute myocardial ischemia were markedly inhibited by the TP. The relationship of dose effect was observed. Conclusion: TP has inhibitory effect of trans membranous signal system of acute ischemic myocardium. It has protective effect on myocardium.
  • 摘要：Chronic primary immune thrombocytopenia(CITP) is the most common acquired autoimmune disease that seriously threaten the physical and mental health of patients. Compared with Western medicine treatment, the intervention and treatment of Chinese medicine(CM) has shown certain therapeutic advantages. This paper reviewed the new pathogenesis progress on T cell immune abnormality in CITP, and CM studies on interferes effects of cellular immune regulation of CITP in recent years. Qi deficiency failing to control blood and internal obstruction of blood stasis are the two common types of CM syndromes in CITP patients, the corresponding treatments include invigorating Pi(Spleen), supplementing qi, activating blood, as well as tonifying qi and activating yang, regulating Gan(Liver) to invigorate Pi. The authors also mentioned the problems in the research field of CM for CTIP treatment, and put forward new ideas for the research in the future.
  • 摘要：WANG Ling-tai,born in 1940,graduated from the Department of Clinical Medicine of Shanghai Medical College in 1963. He is now a Professor, chief physician,and PhD supervisor of Shuguang Hospital,Affiliated to the Shanghai University of Traditional Chinese Medicine.Prof.Wang is the ex-president of Shuguang Hospital,the director of the Coordination Group,National Liver Disease,
  • 摘要：Objective:To investigate the effect of Buyang Huanwu Decoction(补阳还五汤,BYHWD) on estradiol(E_2) and estradiol receptor(ER) in serum and brain in ovariectomized rats after middle cerebral artery occlusion(MCAO).Methods:Adult female rats were ovariectomized and focal cerebral ischemic was induced by MCAO.Rats were randomly divided into normal,ovariectomy(OVX),MCAO,OVX+MCAO,OVX+MCAO+E_2,and OVX+MCAO+BYHWD group.Rats were administered BYHWD 5 g/kg daily,estradiol valerate 500 μg/kg per day or distilled water for 7 consecutive days.Neuronal function and infarct volume were measured on day 7 after artery occlusion,and E_2 and ER concentration in serum and brain were checked by enzyme-linked immunosorbent assay.Results:BYHWD significantly improved the neurological behavior,reduced the infarction volume,increased E_2concentration in serum and brain,and increased ER concentration in the brain in ovariectomized rats after MCAO.Conclusion:The neuroprotective effects of BYHWD are associated with estrogen and its receptor.
  • 摘要：肝纤维变性和 hepatocellular 癌(HCC ) 是世界范围的新兴的健康问题。死亡的数字稳定地在最后十年期间由于 HCC 被增加。尽管肝纤维变性和 HCC 广泛地被调查了，为有 HCC 的病人特别没有成功或令人满意的治疗。从我们西方的药和中国药的理解，它能与象骨头那样的中国药为干预在肝纤维变性和 HCC 识别目标形态基因的蛋白质 4 (BMP-4 ) 。BMP-4 表示显著地在肝纤维变性和 HCC 被增加，某些中国植物的 saponin 班能调整它的表示。因此， BMP-4 能从综合的药是为肝纤维变性和 HCC 的治疗的目标之一。
  • 摘要：ＣｌｉｎｉｃａｌＯｂｓｅｒｖａｔｉｏｎｏｎＥｆｆｅｃｔｏｆＳａｌｖｉａｅＭｉｌｔｉｏｒｒｈｉｚａｅＩｎｊｅｃｔｉｏｎａｎｄＳｎａｋｅＶｅｎｏｍＡｎｔｉｔｈｒｏｍｂｕｓＥｎｚｙｍｅｉｎＴｒｅａｔｉｎｇＰａｔｉｅｎｔｗｉｔｈＡｃｕｔｅＡｔｔａｃｋｏｆＣｈ...
  • 摘要：We recently read the paper entitled"Acupoint catgut embedding alleviates insomnia in different Chinese medicine syndrome types:a randomized controlled trial"by XU,et al.(1)The article elaborated on the effect and safety evaluation of acupoint catgut embedding for different Chinese medicine(CM)syndrome types of insomnia.As a randomized controlled trial article,it has rigorous design,clear inclusion and exclusion criteria,reasonable grouping.
  • 摘要：Objective:To evaluate the effect of Spirulina platensis polysaccharide (SPP) on hematopoietic recovery and related cytokines in mice with transplanted tumor after chemotherapy. Methods:Mouse model of transplanted solid tumor was established and treated with chemotherapy. Peripheral blood cells, bone marrow nucleated cells, and colony forming unit spleen (CFU S) were counted; the content of DNA in bone marrow was inspected by ultraviolet spectrophotometer; serum content of cytokines, interleukin (IL)1, IL 3, granulocyte macrophage colony stimulating factor (GM CSF) and tumor necrosis factor α (TNF α) were determined by double antibody sandwich ELISA.Results:Cyclophosphamide (CTX) could induce evident myelosuppression, manifested as decrease of peripheral blood cells, bone marrow nucleated cell and DNA, and the CFU S number. SPP could significantly ameliorate the myelosuppression induced by CTX without reducing anti tumor effect of CTX. In addition, it could also increase the contents of IL 1, IL 3, GM CSF, TNF α in serum. Conclusion:SPP can probably accelerate the hematopoietic recovery in mice after chemotherapy through promoting endogenous secretion of cytokines.
  • 摘要：Objective:To identify cancer distribution and treatment requirements,a questionnaire on cancer patients was conducted.It was our objective to validate a series of symptoms commonly used in traditional Chinese medicine (TCM).Methods:The M.D.Anderson Symptom Assessment Inventory (MDASI) was used with 10 more TCM items added.Questions regarding TCM application requested in cancer care were also asked.A multi-center,cross-sectional study was conducted in 340 patients from 4 hospitals in Beijing and Dalian.SPSS and Excel software were adopted for statistical analysis.The questionnaire was self-evaluated with the Cronbach's alpha score.Results:The most common symptoms were fatigue 89.4%,sleep disturbance 74.4%,dry mouth 72.9%,poor appetite 72.9%,and difficulty remembering 71.2%.These symptoms affected work (89.8%),mood (82.6%), and activity (76.8%),resulting in poor quality of life.Eighty percent of the patients wanted to regulate the body with TCM.Almost 100% of the patients were interested in acquiring knowledge regarding the integrated traditional Chinese medicine (TCM) and Western medicine (WM) in the treatment and rehabilitation of cancer.Cronbach's alpha score indicated that there was acceptable internal consistency within both the MDASI and TCM items,0.86 for MDASI,0.78 for TCM,and 0.90 for MDASI- TCM (23 items).Conclusions:Fatigue,sleep disturbance,dry mouth,poor appetite,and difficulty remembering are the most common symptoms in cancer patients.These greatly affect the quality of life for these patients.Patients expressed a strong desire for TCM holistic regulation.The MDASI and its TCM-adapted model could be a critical tool for the quantitative study of TCM symptoms.
  • 摘要：Objective:To observe the clinical effectiveness of a topical application of Xiaozheng Zhitong Paste(消癥止痛方,XZP)in alleviating the cancerous pain of patients with middle/late stage cancer.Methods:By adopting a random number table,124 patients enrolled were randomized into the treatment group(64 patients) and the control group(60 patients).In addition to the basic therapy[including the three-ladder(3L)analgesia] used in both groups,topical application of XZP was given to patients in the treatment group for pain alleviation. The analgesic efficacy was recorded in terms of pain intensity,analgesia initiating time and sustaining time, and the optimal analgesic effect revealing time.Meanwhile,the quality of life(QOL)and adverse reactions that occurred in patients were recorded as well.Results:The total effective rate in the treatment group was 84.38%(54/64),and in the control group it was 88.33%(53/60),showing no significant difference between them(P>0.05),but the analgesia initiating time and the optimal analgesia effect revealing time in the treatment group were significantly shorter(both P<0.01).Moreover,XZP was better in improving patients' QOL,showing more significant improvements in the treatment group than those in the control group in aspects of mental condition,walking capacity,working capacity,social acceptability,sleep and joy of living(P<0.05 or P<0.01). Lower incidence of adverse reactions,such as nausea,vomiting,mouth dryness,dizziness,etc.,especially constipation,was noted in the treatment group(P<0.05 or P<0.01).Conclusion:Applying an external compress of XZP showed a synergistic action with 3L analgesia for shortening the initiating time and the optimal effect revealing time,and could evidently enhance patients' QOL with fewer adverse reactions.
  • 摘要：Objectives: To explore the protective effects of Tongmai Yizhi Decoction(通脉益智汤, TYD), a Chinese herb complex prescription against the impairment of cognitive functions and memory loss in amyloid beta 1–40(Aβ1-40) peptide and ibotenic(IBO)-induced Alzheimer's disease(AD) model rats. Methods: The in vivo model was established by injecting Aβ1-40 and IBO into left hippocampal CA1 area of Sprague-Dawley(SD) rat to mimic AD. Totally 32 SD rats were divided into 4 groups, including sham operation group, AD model group, TYD group [AD rats treated with TYD at the dosage of 19.44 g/(kg·d) for 4 weeks] and huperzine A group [AD rats treated with huperzine A at the dosage of 40.5 μg/(kg·d) for 4 weeks]. Spatial learning and memory level was detected by Morris Water Maze test. Histological morphology in the hippocampus was tested by hematoxylin-eosin(HE) staining. Cyclin-dependent kinase-5(Cdk5) protein and gene expression level were investigated by Western blot analysis and real-time quantitative polymerase chain reaction(RT-q PCR), respectively. Results: Aβ1-40 and IBO treatment induced longer escape latency of rats, compared with sham operation group from day 25(P0.05). Furthermore, HE staining also showed that TYD and huperzine A reversed the neuropathological changes in the hippocampus triggered by Aβ1-40 and IBO. TYD and huperzine A effectively reduced the expression levels of Cdk5 protein and gene located in rat hippocampus, compared with the AD model group(P<0.01). Conclusion: TYD could be a promising neuroprotective agent for protecting neuron from AD injury through inhibiting Cdk5 expression.
  • 摘要：目的将在基后面在尿保留上观察针灸治疗效果：子宫切除。
  • 摘要：ＳｔｕｄｙｆｏｒｔｈｅＭｅｃｈａｎｉｓｍｓｏｆＡｃｕｐｕｎｃｔｕｒｅＡｎａｌｇｅｓｉａＨａｎＪｉ－ｓｈｅｎｇ（韩济生）；（ＮｅｕｒｏｓｃｉｅｎｃｅＲｅｓｅａｒｃｈＣｅｎｔｅｒ．ＢｅｉｊｉｎｇＭｅｄｉｃａｌＵｎｉｖｅｒｓｉｔｙ．Ｂｅｉｊｉｎｇ）（１００...
  • 摘要：Ｔｈｅ４ｔｈＮａｔｉｏｎａｌＣｏｎｇｒｅｓｓｏｆＣｈｏＨｅｌｄｉｎＢｅｌｊｉｎｇＴｈｅ４ｔｈｎａｔｉｏｎａｌｃｏｎｇｒｅｓｓｏｆＣｈｉｎｅｓｅＡｓｓｏｃｉａｔｉｏｎｏｆｔｈｅＩｎｔｅｇｒａｔｉｏｎｏｆＴｒａｄｉｔｉｏｎａｌａｎｄＷｅｓｔｅｒｎＭｅｄｉ...
  • 摘要：Objective: To study the effects of Jianpi Qingre Huayu Recipe (健脾清热化瘀方, JQH) in curing gastric ulcer and to preliminarily probe into its pathogenic mechanism. Methods: Fifty patients with gastric ulcer of Pi (脾)-insufficiency and stasis-heat syndrome type were assigned to the treated group (30 patients) and the control group (20 patients). They were treated respectively with JQH and Ranitidine. At the same time, another group consisting of 20 healthy persons was set up for normal control. The clinical effect on gastroscopic figure and traditional Chinese medicine (TCM) syndrome were observed. Changes of T-cell subsets and interleukin-8 (IL-8) in serum as well as IL-8 in mucosa around the gastric ulcer were determined before and after treatment by flow cytometry and ELISA. Results: Comparison of the total effective rate on gastroscopic figure in the treated group and the control group (86.7% vs 80.0%) showed insignificant difference, but the cure rate and markedly effective rate in the former (50.0% and 20.0%) was higher than that in the latter (40.0% and 15.0%) respectively. Comparison of the total effective rate on TCM syndrome in the treated group and in the control group (96.7% vs 70.0%) showed insignificant difference, but the cure rate and markedly effective rate in the former (63.3% and 23.3%) was higher than that in the latter (50.0% and 20.0%) respectively. Serum levels of CD3+, CD4+, CD8+ got restored to normal range in the treated group after treatment but it was not so in the control group. IL-8 level in gastric mucosa was improved in both groups but the improvement in the treated group was better. Conclusion: JQH could effectively treat gastric ulcer and partly reduce its recurrence through improving patients' immune function.
  • 摘要：Background:Although percutaneous coronary intervention(PCI)had become widely employed therapeutic procedure for coronary artery disease,stent restenosis limited the benefits of this revascularization and the question how to prevent such events remained unresolved.While numerous empirical observations suggested Tongguan Capsules(通冠胶囊),a patented Chinese Medicine,could decrease frequency and duration of angina pectoris attacks,evidence supporting its efficacy on restenosis remained inadequate.Objective:This trial was designed to determine whether Tongguan Capsules would reduce restenosis rate in patients after successful stent implantation.Methods:Approximately 400 patients undergoing percutaneous coronary stent deployment were enrolled and randomized to control group or Tongguan Capsules(4.5 g/d)for 3 months.All patients received standard anti-platelet,anti-coagulation and lipid-decreasing treatments,concurrently.The primary clinical endpoint was the 12-month incidence of the major adverse cardiovascular events(defined as cardiac death,myocardial infarction,and recurrence of symptoms requiring additional revascularization).The angiographic end point was restenosis rate at 6 months.Conclusion:This study would provide important evidence for the use of Tongguan Capsules in patients after stent implantation in combination with routine therapies,which may significantly reduce incidence of the restenosis so as to potentially improve the clinical outcomes.(registration number:ChiCTR-TRC-ChiCTR-IIR-17011407)
  • 摘要：For decades,the gut has been thought to play an important role in sepsis pathogenesis.Sepsis is a serious life-threatening,chronic condition of an infection caused by dysregulated host immune response in most of the intensive care unit patients.Probiotics have dual roles in polymicrobial sepsis i.e.probiotics may induce sepsis in many cases and may prevent its prognosis in many cases.Experimental evidence from both pre-clinical and clinical studies have demonstrated that probiotic therapy ameliorates various inflammatory mediators such as tumor necrosis factor,interleukin-10(IL-10),IL-6,etc.,in septicemia.In addition,probiotic use was also found to reduce the severity of pathological conditions associated with irritable bowel disorder and prevent development of endocarditis in septicemia.On contrary,probiotic therapy in neonatal and athymic adult mice fail to provide any beneficial effects on mortality and sepsis-induced inflammation.Importantly,in few clinical trials probiotic use was found to aggravate sepsis by promoting inflammatory cascade rather than suppressing it.This review discusses various studies regarding the beneficial or harmful effects associated with probiotic therapy in sepsis.

    中国结合医学杂志：英文版的期刊信息

    • 曾用名：Chinese Journal of Integrated Traditional and Western Medici;中国中西医结合杂志(英文期刊);中国中西医结合杂志;中国中西医结合杂志：英文版;中国中西医结合杂志:英文版;中国中西医结合杂志英文版;中国中西医结合杂志(英文版)
    • 创刊时间：1995
    • 地区：CHINA MAINLAND
    • 语言：中文
    • 热门主题：CHINESE_MEDICINE MEDICINE TREATING TREATMENT ACUPUNCTURE TRADITIONAL PATIENTS DECOCTION CHINESE EFFECT
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      3

      INTEGRATIVE & COMPLEMENTARY MEDICINE:Q3;

      Medicine:Complementary and Alternative Medicine;Medicine (miscellaneous);Pharmacology (medical);

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