极低频磁场诱发氧化应激的研究进展

摘要

Objective: To investigate the effects of extremely low frequency magnetic fields (ELF-MFs) on oxidative stress, the relation between ELF-MFs and health, and the oxidative stress-related mechanism of the effects of ELF-MFs on organism. Methods: Introduction of ELF-MFs and public exposure, oxidative stress, and oxidative stress-related diseases. Review of the papers focused on the ELF-MF induced oxidative stress including research on cells and animals published in the past few years. Results: ELF-MFs can induce oxidative stress in cells and animals, enhance the production of reactive oxygen species and other free radicals, and change the capability of antioxidant defenses. The extent of oxidative stress was related to tissue and organ, rose with duration of exposure and strength of ELF-MFs. Conclusions: In a certain aspect, the effects of ELF-MFs on organism were shown on the stimulation of oxidative stress. Further research on the molecular mechanism of the ELF-MF inducing oxidative stress, characteristic of cell injuries, and the relation between ELF-MFs and oxidative stress-related diseases will disclose the effects of ELF-MFs pnihuman health.%目的:探讨极低频磁场对氧化应激的影响、与人类健康的关系,以及通过氧化应激研究极低频磁场对生物体作用的机制.方法:简要介绍极低频磁场以及职业暴露和公众暴露、氧化应激以及与疾病的关系,对近几年极低频磁场诱发氧化应激的研究论文进行归纳和总结.包括在细胞水平上和动物个体水平上极低频磁场诱发的氧化应激.结果:在细胞和动物个体水平上极低频磁场均能诱发氧化应激反应,提高活性氧和其它自由基的水平,改变抗氧化能力.不同的组织和器官对极低频磁场暴露所产生的氧化应激反应不同.不同的极低频磁场强度和暴露时间对动物所产生的氧化应激反应也不同,表现为随着磁场强度的增大所产生的氧化应激程度越大,随着磁场暴露时间的延长所产生的氧化应激程度越大.结论:氧化应激反应是极低频磁场对生物体作用的一种方式,未来深入具体的研究极低频磁场诱发氧化应激的分子机制,细胞损伤的表征,以及与相关疾病发生的关系将会揭示极低频磁场对人类健康影响.