2型糖尿病患者大脑灰质密度改变及其与认知受损的相关性研究

摘要

目的:利用磁共振成像技术结合基于体素的形态学分析方法,探讨2型糖尿病(T2DM)患者大脑灰质密度改变与糖尿病临床指标及认知功能受损之间的关系.方法:采集31名T2DM患者及32名正常人的大脑磁共振结构像,计算全脑体素的灰质密度,提取存在显著差异脑区的灰质密度与临床指标及认知测试结果进行相关性分析.结果:体素的形态学结果显示,与正常对照组相比,T2DM患者右侧小脑、左侧颞中回、左侧枕中回的灰质密度明显降低(P<0.001).右侧小脑及左侧颞中回的灰质密度分别与简易精神状态检查量表评分呈显著正相关.结论:T2DM患者在小脑、颞叶和枕叶会出现灰质密度降低,且这些脑区的灰质密度降低与患者认知受损有关.%Objectives To investigate the alteration of gray matter density(GMD)and its correlation with clinical indexes and cognitive impairment in patients with type 2 diabetes mellitus(T2DM)by the analysis method combining magnetic resonance imaging with voxel-based morphology.Methods The magnetic resonance images of 31 patients with T2DM and 32 healthy controls were collected,and GMD was calculated.After the GMD of brain regions showing significant differences were extracted, we analyzed the correlation between extracted GMD with clinical indexes and cognitive test results.Results Voxel-based morphology analysis results showed that GMD in the right cerebellum,the left middle temporal gyrus,and the left middle occipital gyrus was significantly reduced in T2DM patients compared to healthy controls(P<0.001).GMD in the right cerebellum and the left middle temporal gyrus was positively correlated with scores of mini-mental state examination.Conclusion T2DM patients develop structural atrophy in the cerebellum,the temporal lobe and the occipital lobe,and the GMD of these brain regions is related to the cognitive impairment in T2DM patients.