18F-FDG PET/CT在寻找不明原发灶肿瘤患者原发灶中的价值

摘要

Purpose To explore the value of 18F-FDG PET/CT in the diagnosis of primary focus for patients with carcinoma of unknown primary (CUP). Materials and Methods Thirty-six patients with CUP underwent PET/CT to detect the primary focus, and further divided into lymph node metastasis group (n = 8), liver metastasis group (n = 9), bone metastasis group (n=12), malignant hydrothorax and ascites group (n= 7) according to sites of metastasis. The sensitivity of diagnosing primary focus in patients with CUP between lymph node metastasis group and non-lymph node metastasis group using PET/CT was analyzed. Results The sensitivity of 18F-FDG PET/CT in detecting primary focus for patients with CUP was 63.9% (23/36), the sensitivities in lymph node metastasis group, liver metastasis group, bone metastasis group, malignant hydrothorax and ascites group were 87.5% (7/8), 55.6% (5/9), 58.3% (7/12), 57.1% (4/7), respectively. The diagnostic rate in lymph node metastasis group [87.5% (7/8)] was statistically higher than that of non-lymph node metastasis group [57.1% (16/28)] (P<0.05). Conclusion 18F-FDG PET/CT is sensitive to diagnose the primary focus for patients with CUP, especially for patients with lymph node metastasis.%目的 探讨18F-FDG PET/CT在诊断不明原发灶肿瘤(CUP)患者原发灶中的价值.资料与方法 36例CUP患者行PET/CT检查拟寻找原发灶,根据转移灶部位分为淋巴结转移组(8例)、肝转移组(9例)、骨转移组(12例)及恶性胸腹水组(7例),比较18F-FDG PET/CT诊断淋巴结转移组与非淋巴结转移组CUP患者原发灶的灵敏度.结果 18F-FDG PET/CT寻找CUP原发灶的灵敏度为63.9％ (23/36),PET/CT诊断淋巴结转移组、肝转移组、骨转移组及恶性胸腹水组患者原发灶的灵敏度分别为87.5％ (7/8)、55.6％ (5/9)、58.3％(7/12)、57.1％ (4/7).18F-FDG PET/CT对淋巴结转移组原发灶的确诊率[87.5％(7/8)]显著高于非淋巴结转移组[57.1％( 16/28)],差异有统计学意义(P＜0.05).结论 18F-FDG PET/CT诊断CUP患者原发灶灵敏度较高,尤其适用于发生淋巴结转移的CUP患者.