临界高血压患者血管内皮功能紊乱的超声观测

摘要

目的　通过高分辨力超声，观测临界高血压患者血管内皮功能是否受到损伤。 方法　对照组及临界高血压患者各10例，通过反应性充血后肱动脉内径变化评估血管内皮功能。 结果　与对照组相比，临界高血压患者内皮依赖性舒张功能明显受损（5.49±3.78 vs 10.11±2.70，P<0.05），而内皮非依赖性舒张功能无明显变化（14.86±4.73 vs 18.36±2.39，P>0.05），其内皮依赖性舒张功能与年龄、血糖、血脂之间无明显的相关性。 结论　高分辨力超声可以早期观测高血压患者内皮功能的改变。%Objective 　To evaluate the endothelial dysfunction by the high-resolution ultrasound in borderline hypertension patients. Methods　 In 10 borderline hypertension patients and 10 control subjects，the endothelial function was evaluated by the high-resolution ultrasound through the diameter change in brachial artery after reactive hyperemia. Results　 The endothelium-depended dilatation was destroyed significantly in borderline hypertension patients than control subjects（5.49±3.78 vs 10.11±2.70 P<0.05），but there was no difference in endothelium-independed dilatation（14.86±4.73 vs 18.36±2.39，P>0.05）. The significant relations between endothelium-depended dilatation and blood surge, total cholesterol, HDL were not found. Conclusion　 High-resolution ultrasound could measured endothelial dysfunction in the early stage of hypertension.