声学造影实时三维超声心动图评价犬急性冠状动脉闭塞的侧支循环

摘要

Objective To evaluate the collateral circulation after canine acute coronary artery occlusion with contrast real-time three-dimensional echocardiography (RT-3DE). Methods Left anterior descending coronary artery was ligated in 12 healthy mongrel dogs. All dogs underwent myocardial contrast echocardiography (MCE) before ligation, immediately after ligation, at 30 min and 180 min after ligation respectively, and myocardial mass with collateral supply was calculated. Results Different degrees of collateral circulation were established in all dogs after left anterior descending coronary artery ligation. At 30 min after ligation, the myocardial mass with collateral supply was (9.65±2.90) g, while at 180 min after ligation were (12.58±3.98) g (P<0.01). Conclusion The coronary collateral circulation can be observed clearly and myocardial mass with collateral supply can be quantified accurately with contrast RT-3DE.%目的 应用声学造影实时三维超声心动图评价急性冠状动脉闭塞犬的侧支循环.方法 结扎12只健康杂种犬左前降支,分别于结扎前、结扎后即刻、结扎后30 min及结扎后180 min时行心肌声学造影观察,并计算供血区心肌重量. 结果左前降支结扎后所有实验犬均有不同程度的侧支循环建立.结扎后30 min,侧支循环供血区心肌重量为(9.65±2.90)g;结扎后180 min,侧支循环供血区心肌重量为(12.58±3.98)g;二者之间差异有统计学意义. 结论 应用声学造影实时三维超声心动图可以很好地显示冠状动脉侧支循环的形成,并获得全面准确的侧支循环区心肌重量.