帕金森病患者静息态下脑活动的局部一致性

摘要

Objective To explore whether abnormal brain activity exists in Parkinson disease (PD) patients during resting state by regional homogeneity (ReHo) approach. Methods fMRI images were obtained in resting state from 16 PD patients (PD group) and 12 healthy subjects (control group). ReHo approach was applied for fMRI data analysis, and correlation test was taken between ReHo of the changed brain regions and unified PD rating scale (UPDRS). Results ?PD patients showed changed ReHo of BOLD signal in resting brain. Decreased ReHo was found in right inferior parietal lobule, left cerebellum posterior lobe, left precuneus and right dorsolateral prefrontal cortex, while increased ReHo was detected over bilateral cerebellum anterior lobe, right inferior temporal gyrus, bilateral lentiform nucleus, bilateral thalamus, left caudate, right supplementary motor cortex and bilateral precentral gyrus. ?Significant positive correlation between ReHo and UPDRS was noticed in several brain regions. Conclusion Abnormal brain activity of PD might exist in resting state. ReHo may be potentially helpful to exploring resting state brain activity in PD.%目的 利用fMRI局部一致性(ReHo)方法探测帕金森病(PD)在静息状态下是否存在脑活动异常.方法 对16例PD患者(PD组)和12名正常对照者(对照组)进行静息状态fMRI,应用ReHo方法处理fMRI数据·得出PD患者ReHo异常的脑区,并对存在组间差异的脑区ReHo与PD综合评分分数(UPDRS)进行相关分析.结果 ①PD组ReHo显著增高的脑区包括双侧小脑前叶、右侧颞下回、双侧豆状核、双侧丘脑、左侧尾状核、右侧辅助运动区和双侧中央前回；ReHo显著降低的脑区为左侧小脑后叶、右侧前额叶背外侧皮层、左侧楔前叶和右侧顶下小叶；②多处PD组与对照组存在差异的脑区ReHo与UPDRS得分呈显著正相关.结论 PD患者在静息状态下即存在脑功能异常；ReHo方法可能有助于研究PD患者静息状态脑活动.