2D NMR对栌菊木中的一个倍半萜内酯进行结构解析

摘要

通过核磁共振对一个首次从菊科单种属植物一栌菊木中分离得到的乌药烷型倍半萜内酯-8β,9-dihydro-onoseriolide进行了结构解析,通过2D NMR(HSQC,HMBC,NOESY)首次对该化合物的碳和氢质子信号进行全归属;并证实其结构中的H-1,H-2互为颠倒,纠正了文献报道中的错误,该研究对乌药烷骨架倍半萜内酯的结构鉴定提供了光谱学依据.%A sesquiterpene lactone was isolated from Nouelia insignis Franch,and its structure was elucidated(compound 1)by 2D NMR to be 8β,9-dihydro-onoseriolide.Complete assignment of the 1H and 13C chemical shifts for the compound was obtained.The assignments of H1 and H-2 of the compound previously reported were found incorrect,and the correct assignments were given.The results of this study may have some practical significance for the structural elucidation of onoseriolide sesquiterpene lactones.